Host range of chlamydiaphages fCPAR39 and Chp3
Host range of chlamydiaphages fCPAR39 and Chp3
The host range of CPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that CPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.
6490-6492
Everson, J.S.
8f5e2cbc-b8f9-4ba6-9140-d726764d6c14
Garner, S.A.
0965edba-1d1f-4080-85a0-41b53d3cb553
Lambden, P.R.
e99ecc21-50d7-4a43-9e79-efba46592c77
Fane, B.A.
1a159e8d-9b55-404c-b755-313695ba75ff
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
2003
Everson, J.S.
8f5e2cbc-b8f9-4ba6-9140-d726764d6c14
Garner, S.A.
0965edba-1d1f-4080-85a0-41b53d3cb553
Lambden, P.R.
e99ecc21-50d7-4a43-9e79-efba46592c77
Fane, B.A.
1a159e8d-9b55-404c-b755-313695ba75ff
Clarke, I.N.
ff6c9324-3547-4039-bb2c-10c0b3327a8b
Everson, J.S., Garner, S.A., Lambden, P.R., Fane, B.A. and Clarke, I.N.
(2003)
Host range of chlamydiaphages fCPAR39 and Chp3.
Journal of Bacteriology, 185 (21), .
(doi:10.1128/JB.185.21.6490-6492.2003).
Abstract
The host range of CPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that CPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.
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Published date: 2003
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Local EPrints ID: 27042
URI: http://eprints.soton.ac.uk/id/eprint/27042
ISSN: 0021-9193
PURE UUID: 287009b1-5b72-4a01-ba05-7092f03a729c
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Date deposited: 28 Apr 2006
Last modified: 16 Mar 2024 02:33
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Contributors
Author:
J.S. Everson
Author:
S.A. Garner
Author:
P.R. Lambden
Author:
B.A. Fane
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