The University of Southampton
University of Southampton Institutional Repository

Evaluation of the accuracy and precision of lung aerosol deposition measurements from single-photon emission computed tomography using simulation

Evaluation of the accuracy and precision of lung aerosol deposition measurements from single-photon emission computed tomography using simulation
Evaluation of the accuracy and precision of lung aerosol deposition measurements from single-photon emission computed tomography using simulation
Single-photon emission computed tomography (SPECT) imaging is being increasingly used to assess inhaled aerosol deposition. This study uses simulation to evaluate the errors involved in such measurements and to compare them with those from conventional planar imaging. SPECT images of known theoretical distributions of radioaerosol in the lung have been simulated using lung models derived from magnetic resonance studies in human subjects. Total lung activity was evaluated from the simulated images. A spherical transform of the lung distributions was performed, and the absolute penetration index (PI) and a relative value expressed as a fraction of that in a simulated ventilation image were calculated. All parameters were compared with the true value used in the simulation, and the errors were assessed. An iterative method was used to correct for the partial volume effect, and its effectiveness in improving errors was evaluated.
The errors were compared with those of planar imaging. The precision of measurements was significantly better for SPECT than planar imaging (2.8 vs 6.3% for total lung activity, 6 vs 20% for PI, and 3 vs 6% for relative PI). The method of correcting for the influence of the partial volume effect significantly improved the accuracy of PI evaluation without affecting precision. SPECT is capable of accurate and precise measurements of aerosol distribution in the lung, which are improved compared with those measured by conventional planar imaging. A technique for correcting the SPECT data for the influence of the partial volume effect has been described. Simulation is demonstrated as a valuable method of technique evaluation and comparison.
187-198
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Sauret, V.
0d7473f2-3cc7-483e-b21e-de6515940b18
Conway, J.H.
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bailey, A.G.
4d3e6ad9-acd7-495f-8a49-c77c9e20df5a
Martonen, T.B.
dd064c81-9ebc-40bb-97df-be689787fc8e
Fleming, J.S.
bf089a52-bc49-402a-9129-0dfecf452936
Sauret, V.
0d7473f2-3cc7-483e-b21e-de6515940b18
Conway, J.H.
bbe9a2e4-fb85-4d4a-a38c-0c1832c32d06
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Bailey, A.G.
4d3e6ad9-acd7-495f-8a49-c77c9e20df5a
Martonen, T.B.
dd064c81-9ebc-40bb-97df-be689787fc8e

Fleming, J.S., Sauret, V., Conway, J.H., Holgate, S.T., Bailey, A.G. and Martonen, T.B. (2000) Evaluation of the accuracy and precision of lung aerosol deposition measurements from single-photon emission computed tomography using simulation. Journal of Aerosol Medicine, 13 (3), 187-198.

Record type: Article

Abstract

Single-photon emission computed tomography (SPECT) imaging is being increasingly used to assess inhaled aerosol deposition. This study uses simulation to evaluate the errors involved in such measurements and to compare them with those from conventional planar imaging. SPECT images of known theoretical distributions of radioaerosol in the lung have been simulated using lung models derived from magnetic resonance studies in human subjects. Total lung activity was evaluated from the simulated images. A spherical transform of the lung distributions was performed, and the absolute penetration index (PI) and a relative value expressed as a fraction of that in a simulated ventilation image were calculated. All parameters were compared with the true value used in the simulation, and the errors were assessed. An iterative method was used to correct for the partial volume effect, and its effectiveness in improving errors was evaluated.
The errors were compared with those of planar imaging. The precision of measurements was significantly better for SPECT than planar imaging (2.8 vs 6.3% for total lung activity, 6 vs 20% for PI, and 3 vs 6% for relative PI). The method of correcting for the influence of the partial volume effect significantly improved the accuracy of PI evaluation without affecting precision. SPECT is capable of accurate and precise measurements of aerosol distribution in the lung, which are improved compared with those measured by conventional planar imaging. A technique for correcting the SPECT data for the influence of the partial volume effect has been described. Simulation is demonstrated as a valuable method of technique evaluation and comparison.

Full text not available from this repository.

More information

Published date: 2000

Identifiers

Local EPrints ID: 27045
URI: http://eprints.soton.ac.uk/id/eprint/27045
PURE UUID: 3cb9ebc6-0c99-400e-95a6-a17c389d8442
ORCID for J.H. Conway: ORCID iD orcid.org/0000-0001-6464-1526

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 15 Jul 2019 19:13

Export record

Contributors

Author: J.S. Fleming
Author: V. Sauret
Author: J.H. Conway ORCID iD
Author: S.T. Holgate
Author: A.G. Bailey
Author: T.B. Martonen

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×