The University of Southampton
University of Southampton Institutional Repository

What can we learn about asthma from studying occupational asthma?

Frew, Anthony J. (2003) What can we learn about asthma from studying occupational asthma? Annals of Allergy, Asthma and Immunology, 90, (5 sup. 1), pp. 7-10.

Record type: Article

Abstract

Objective: To review the clinical features and underlying mechanisms of occupational asthma in an attempt to glean insights into various other forms of asthma.
Data Sources: Published literature, including consensus guidelines on diagnosis and management of occupational asthma.
Study Selection: This article represents a synthesis of these data sources and the opinion of the author.
Results: Occupational asthma may be caused by a variety of mechanisms, including both IgE-dependent and non-IgE-dependent immunological processes. IgE-dependent mechanisms are responsible for reactions to all high-molecular-weight occupational antigens and to some but not all low-molecular-weight antigens. Factors in sensitization and onset include the general genetic predisposition to make IgE and the specific responsiveness of the individual to particular allergens. Once sensitized, the main factor that influences the onset of symptoms is the degree of exposure. In general, the higher the level of exposure, the more likely the sensitized person is to develop asthma.
Conclusions: Occupational asthma can be induced by a variety of agents that appear to use different mechanisms to affect the airway. Studies of the remission of occupational asthma indicate that resolution is a slow process. However, the study of occupational asthma may eventually allow us to identify treatments that will accelerate remission or induce remission in other forms of asthma.

Full text not available from this repository.

More information

Published date: 2003

Identifiers

Local EPrints ID: 27052
URI: http://eprints.soton.ac.uk/id/eprint/27052
ISSN: 1081-1206
PURE UUID: e2f55583-81f0-4812-9d9d-3f36a88a9d78

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 17 Jul 2017 16:05

Export record

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×