25. Immunotherapy of allergic disease
25. Immunotherapy of allergic disease
Specific immunotherapy involves the administration of allergen extracts to achieve clinical tolerance of the allergens which cause symptoms in patients with allergic conditions. Immunotherapy has been shown to be effective in patients with mild forms of allergic disease, and also in those who do not respond well to standard drug therapy.
Recent studies suggest that specific immunotherapy may also modify the course of allergic disease, by reducing the risk of developing new allergic sensitizations, and also inhibiting the development of clinical asthma in children treated for allergic rhinitis. Specific immunotherapy remains the treatment of choice for patients with systemic allergic reactions to wasp and bee stings.
The precise mechanisms responsible for the beneficial effects of SIT remain a matter of research and debate. An effect on regulatory T cells seems most probable, associated with switching of allergen-specific B cells towards IgG4 production. Few direct comparisons of specific immunotherapy and drug therapy have been made. Existing data suggest that the effects of specific immunotherapy take longer to come on, but once established, specific immunotherapy will give long-lasting relief of allergic symptoms, whereas the benefits of drugs only last as long as they are continued. (J Allergy Clin Immunol 2003;111:S712-9.)
immunotherapy, immunomodulation, rhinitis, asthma, t cell, b cell, igg, igc
S712-S719
Frew, Anthony J.
4887b766-67c6-4d69-940d-4c06c0890b76
2003
Frew, Anthony J.
4887b766-67c6-4d69-940d-4c06c0890b76
Frew, Anthony J.
(2003)
25. Immunotherapy of allergic disease.
Journal of Allergy and Clinical Immunology, 111 (2 Suppl), .
(doi:10.1067/mai.2003.84).
Abstract
Specific immunotherapy involves the administration of allergen extracts to achieve clinical tolerance of the allergens which cause symptoms in patients with allergic conditions. Immunotherapy has been shown to be effective in patients with mild forms of allergic disease, and also in those who do not respond well to standard drug therapy.
Recent studies suggest that specific immunotherapy may also modify the course of allergic disease, by reducing the risk of developing new allergic sensitizations, and also inhibiting the development of clinical asthma in children treated for allergic rhinitis. Specific immunotherapy remains the treatment of choice for patients with systemic allergic reactions to wasp and bee stings.
The precise mechanisms responsible for the beneficial effects of SIT remain a matter of research and debate. An effect on regulatory T cells seems most probable, associated with switching of allergen-specific B cells towards IgG4 production. Few direct comparisons of specific immunotherapy and drug therapy have been made. Existing data suggest that the effects of specific immunotherapy take longer to come on, but once established, specific immunotherapy will give long-lasting relief of allergic symptoms, whereas the benefits of drugs only last as long as they are continued. (J Allergy Clin Immunol 2003;111:S712-9.)
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Published date: 2003
Keywords:
immunotherapy, immunomodulation, rhinitis, asthma, t cell, b cell, igg, igc
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Local EPrints ID: 27054
URI: http://eprints.soton.ac.uk/id/eprint/27054
ISSN: 0091-6749
PURE UUID: ec072de9-5b68-4615-a4f5-7cc1beb5c121
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Date deposited: 26 Apr 2006
Last modified: 15 Mar 2024 07:15
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Author:
Anthony J. Frew
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