The University of Southampton
University of Southampton Institutional Repository

Microfluidic array platform for simultaneous lipid bilayer membrane formation

Zagnoni, M., Sandison, M.E. and Morgan, H. (2009) Microfluidic array platform for simultaneous lipid bilayer membrane formation Biosensors & Bioelectronics, 24, (5), pp. 1235-1240. (PMID:18760585).

Record type: Article


In recent years, protein array technologies have found widespread applications in proteomics. However, new methods for high-throughput analysis of protein-protein and protein-compound interactions are still required. In this paper, an array of lipid bilayer membranes formed within a microfluidic system with integrated electrodes is presented. The system is comprised of three layers that are clamped together, thus rendering the device cleanable and reusable. The device microfluidics enable the simultaneous formation of an array of lipid bilayers using a previously developed air-exposure technique, thereby avoiding the need to manually form individual bilayers. The Ag/AgCl electrodes allow for ion channel measurements, each of the sites being independently addressable. Typically, a 50% yield in simultaneous lipid bilayer formation over 12 sites was obtained and ion channel recordings have been acquired over multiple sites. This system has great potential for the development of an automatable platform of suspended lipid bilayer arrays

Full text not available from this repository.

More information

Published date: 2009
Organisations: Nanoelectronics and Nanotechnology


Local EPrints ID: 270657
ISSN: 0956-5663
PURE UUID: c7715126-27ac-4926-909f-61aaad460158
ORCID for H. Morgan: ORCID iD

Catalogue record

Date deposited: 21 Apr 2010 07:46
Last modified: 05 Oct 2017 07:22

Export record


Author: M. Zagnoni
Author: M.E. Sandison
Author: H. Morgan ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.