Gray, Carolyn, McCormick, Christopher, Turner, Gareth and Craig, Alister
ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow
Molecular and Biochemical Parasitology, 128, (2), . (doi:10.1016/S0166-6851(03)00075-6).
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We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (?98%) of adhesion.
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