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ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow

Gray, Carolyn, McCormick, Christopher, Turner, Gareth and Craig, Alister (2003) ICAM-1 can play a major role in mediating P. falciparum adhesion to endothelium under flow Molecular and Biochemical Parasitology, 128, (2), pp. 187-193. (doi:10.1016/S0166-6851(03)00075-6).

Record type: Article

Abstract

We have investigated the importance of adhesion molecule co-operation in mediating Plasmodium falciparum adhesion to endothelial cells under flow conditions. Using three laboratory parasite lines and a patient isolate which differ in their ICAM-1 and CD36-binding avidity, we found that blockade of ICAM-1 and CD36 separately reduced IRBC adhesion by up to 95 and 50%, respectively. These results confirm previous data showing that ICAM-1 and CD36 synergize to mediate adhesion, but differ in demonstrating that without ICAM-1, binding under flow conditions is severely impaired. Thus, in this system, ICAM-1 is critical for P. falciparum adhesion to activated endothelium and once bound, synergy with CD36 mediates the majority (?98%) of adhesion.

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Published date: 2003
Keywords: icam-1, cd36, plasmodium falciparum, adhesion, hdmec, huvec

Identifiers

Local EPrints ID: 27073
URI: http://eprints.soton.ac.uk/id/eprint/27073
ISSN: 0166-6851
PURE UUID: f989338f-69de-43f5-a776-c77bf2db8c68

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:05

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Contributors

Author: Carolyn Gray
Author: Christopher McCormick
Author: Gareth Turner
Author: Alister Craig

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