The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation

Holgate, S., Casale, T., Wenzel, S., Bousquet, J., Deniz, Y. and Reisner, C. (2005) The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. Journal of Allergy and Clinical Immunology, 115 (3), 459-465. (doi:10.1016/j.jaci.2004.11.053).

Abstract

Anti-IgE therapy with omalizumab reduces serum levels of free IgE and downregulates expression of IgE receptors (Fc?RI) on mast cells and basophils. In the airways of patients with mild allergic asthma, omalizumab reduces Fc?RI+ and IgE+ cells and causes a profound reduction in tissue eosinophilia, together with reductions in submucosal T-cell and B-cell numbers. In patients with seasonal allergic rhinitis, omalizumab inhibits the allergen-induced seasonal increases in circulating and tissue eosinophils. Omalizumab decreases Fc?RI expression on circulating dendritic cells, which might lead to a reduction in allergen presentation, TH2 cell activation, and proliferation. As a systemic anti-IgE agent, omalizumab has demonstrated clinical efficacy in patients with moderate and severe allergic asthma and in those with seasonal and perennial allergic rhinitis, as well as in patients with concomitant allergic asthma and allergic rhinitis. The anti-inflammatory effects of omalizumab at different sites of allergic inflammation and the clinical benefits of anti-IgE therapy in patients with allergic asthma and allergic rhinitis emphasize the fundamental importance of IgE in allergic inflammation.
Abbreviations used: BHR, Bronchial hyperresponsiveness; EAR, Early asthmatic response; ICS, Inhaled corticosteroid; LAR, Late asthmatic response; pDC, Precursor dendritic cell; SAR, Seasonal allergic rhinitis

This record has no associated files available for download.

Contributors

Download statistics