Airway inflammation and remodeling in asthma: current concepts
Airway inflammation and remodeling in asthma: current concepts
Asthma is a chronic inflammatory disorder of the airways interacting with altered structure and function of the formed elements including smooth muscle. While atopy and polarization of the airway T-cell response toward a Th-2 phenotype are important factors in asthma pathogenesis, there is increasing realization that remodeling events are also important. Evidence is presented that inflammation and altered airway structure in asthma interact through the epithelium and underlying mesenchyme. As in other chronic inflammatory disorders, a dynamic interplay between mediators, cytokines, and growth factors provides a broader base on which to identify novel preventative and therapeutic strategies in asthma.
asthma, mediators, inflammation, remodeling
179-189
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
2002
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holgate, Stephen T.
(2002)
Airway inflammation and remodeling in asthma: current concepts.
Molecular Biotechnology, 22 (2), .
Abstract
Asthma is a chronic inflammatory disorder of the airways interacting with altered structure and function of the formed elements including smooth muscle. While atopy and polarization of the airway T-cell response toward a Th-2 phenotype are important factors in asthma pathogenesis, there is increasing realization that remodeling events are also important. Evidence is presented that inflammation and altered airway structure in asthma interact through the epithelium and underlying mesenchyme. As in other chronic inflammatory disorders, a dynamic interplay between mediators, cytokines, and growth factors provides a broader base on which to identify novel preventative and therapeutic strategies in asthma.
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Published date: 2002
Keywords:
asthma, mediators, inflammation, remodeling
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Local EPrints ID: 27106
URI: http://eprints.soton.ac.uk/id/eprint/27106
ISSN: 1073-6085
PURE UUID: e45f8087-9111-4ef7-a8dd-b37c9a4881cf
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Date deposited: 27 Apr 2006
Last modified: 08 Jan 2022 15:52
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