New targets for allergic rhinitis--a disease of civilization

Holgate, Stephen T. and Broide, David (2003) New targets for allergic rhinitis--a disease of civilization. Nature Reviews. Drug Discovery, 2 (11), 902-914. (doi:10.1038/nrd1224).

Record type: Article

Abstract

Allergic rhinitis is an inflammatory disorder of the nasal mucosa, mediated by TH2 lymphocytes, which is linked to atopy and whose prevalence is increasing in association with a Western lifestyle. The production of allergen-specific IgE, activation of mucosal mast cells and the recruitment and activation of effector leukocytes provides potential therapeutic targets, including selective inhibition of cytokines, adhesion molecules and signalling pathways. Blockade of IgE, using monoclonal antibodies and vaccine strategies, is a new approach for interrupting the allergic cascade, whereas the use of recombinant mutated allergens, peptides and DNA oligonucleotides will lead to improved efficacy and reduced side effects of immunotherapy to induce tolerance.

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