Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma
Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma
The aims of this article are to understand the shortfalls in thinking of asthma purely as an atopic disorder, to gain insight into the epithelial abnormalities of asthma and how these interface with the environment, and to view asthma as a disease of airway wall restructuring that engages activation of the epithelial mesenchymal trophic unit (EMTU). Furthermore, based on these developments, possible novel therapeutic targets for chronic asthma are identified.
24s-29s
Holgate, S.T.
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Davies, D.E.
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Puddicombe, S.
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Richter, A.
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Lackie, P.
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Lordan, J.
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Howarth, P.
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2003
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Davies, D.E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Puddicombe, S.
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Richter, A.
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Lackie, P.
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Lordan, J.
c7a31d0c-ffa9-4073-a5e5-4ca166e9df14
Howarth, P.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Holgate, S.T., Davies, D.E., Puddicombe, S., Richter, A., Lackie, P., Lordan, J. and Howarth, P.
(2003)
Mechanisms of airway epithelial damage: epithelial-mesenchymal interactions in the pathogenesis of asthma.
European Respiratory Journal Supplement, 44, .
(doi:10.1183/09031936.03.00000803).
Abstract
The aims of this article are to understand the shortfalls in thinking of asthma purely as an atopic disorder, to gain insight into the epithelial abnormalities of asthma and how these interface with the environment, and to view asthma as a disease of airway wall restructuring that engages activation of the epithelial mesenchymal trophic unit (EMTU). Furthermore, based on these developments, possible novel therapeutic targets for chronic asthma are identified.
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Published date: 2003
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Local EPrints ID: 27114
URI: http://eprints.soton.ac.uk/id/eprint/27114
ISSN: 0904-1850
PURE UUID: 764f3113-b850-478d-a724-8704b5a0be5e
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Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 02:45
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Author:
S. Puddicombe
Author:
A. Richter
Author:
J. Lordan
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