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Developmental motifs reveal complex structure in cell lineages

Geard, Nicholas, Bullock, Seth, Lohaus, Rolf, Azevedo, Ricardo B.R. and Wiles, Janet (2011) Developmental motifs reveal complex structure in cell lineages Complexity, 16, (4), pp. 48-57. (doi:10.1002/cplx.20341).

Record type: Article

Abstract

Many natural and technological systems are complex, with organisational structures that exhibit characteristic patterns, but defy concise description. One effective approach to analysing such systems is in terms of repeated topological motifs. Here, we extend the motif concept to characterise the dynamic behaviour of complex systems by introducing developmental motifs, which capture patterns of system growth. As a proof of concept, we use developmental motifs to analyse the developmental cell lineage of the nematode Caenorhabditis elegans, revealing a new perspective on its complex structure. We use a family of computational models to explore how biases arising from the dynamics of the developmental gene network, as well as spatial and temporal constraints acting on development, contribute to this complex organisation.

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More information

e-pub ahead of print date: 17 August 2010
Published date: March 2011
Keywords: cell lineages, development, gene regulatory networks, generative bias, motifs
Organisations: Agents, Interactions & Complexity

Identifiers

Local EPrints ID: 271194
URI: http://eprints.soton.ac.uk/id/eprint/271194
PURE UUID: fe74b8ec-5b6e-4e09-8bab-4d74942b84dd

Catalogue record

Date deposited: 27 May 2010 17:34
Last modified: 18 Jul 2017 06:46

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Contributors

Author: Nicholas Geard
Author: Seth Bullock
Author: Rolf Lohaus
Author: Ricardo B.R. Azevedo
Author: Janet Wiles

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