ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma
Asthma is known to be a Th2 inflammatory syndrome that leads to intermittent airway obstruction. However, the mechanisms involved in development of the clinical features remain enigmatic, although genetic elements clearly are involved. Recently, based on a large genomewide screen involving families in the United Kingdom and the United States with at least two siblings with asthma, a locus was identified that encoded for a family of proteases. This group of proteins is now known as the ADAM superfamily. In this review, we discuss the ADAM superfamily and, in particular, ADAM 33, a member of a family of genes which encode a subgroup of zinc dependent metalloproteinase (metzincin). The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity.
Metalloproteinase, bronchial hyperreactivity, ADAM, T helper–2 inflammation
23-34
Holgate, Stephen T.
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Davies, Donna E.
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Rorke, Steuart
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Cakebread, Julie
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Murphy, Gillian
bc20be6b-53b4-47ca-8604-f9fad120bb77
Powell, Robert M.
884d6594-3f50-4be5-9516-d64b29dad63d
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
2004
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Rorke, Steuart
0b362590-4c4d-47f6-b09b-988ae79f6994
Cakebread, Julie
51e36732-a222-4cc3-ab7f-b89e60a78fb5
Murphy, Gillian
bc20be6b-53b4-47ca-8604-f9fad120bb77
Powell, Robert M.
884d6594-3f50-4be5-9516-d64b29dad63d
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Holgate, Stephen T., Davies, Donna E., Rorke, Steuart, Cakebread, Julie, Murphy, Gillian, Powell, Robert M. and Holloway, John W.
(2004)
ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma.
Clinical Reviews in Allergy & Immunology, 27 (1), .
Abstract
Asthma is known to be a Th2 inflammatory syndrome that leads to intermittent airway obstruction. However, the mechanisms involved in development of the clinical features remain enigmatic, although genetic elements clearly are involved. Recently, based on a large genomewide screen involving families in the United Kingdom and the United States with at least two siblings with asthma, a locus was identified that encoded for a family of proteases. This group of proteins is now known as the ADAM superfamily. In this review, we discuss the ADAM superfamily and, in particular, ADAM 33, a member of a family of genes which encode a subgroup of zinc dependent metalloproteinase (metzincin). The potential for therapeutic intervention with ADAM 33 is extremely attractive and further work will not only focus on the specific domains of ADAM 33, but also the mechanisms by which they lead to bronchial hyperreactivity.
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Published date: 2004
Keywords:
Metalloproteinase, bronchial hyperreactivity, ADAM, T helper–2 inflammation
Identifiers
Local EPrints ID: 27121
URI: http://eprints.soton.ac.uk/id/eprint/27121
PURE UUID: 86b40642-1531-48c3-95f2-edb3faf44e79
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Date deposited: 27 Apr 2006
Last modified: 07 Jul 2022 01:37
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Contributors
Author:
Steuart Rorke
Author:
Julie Cakebread
Author:
Gillian Murphy
Author:
Robert M. Powell
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