The discovery and role of ADAM33, a new candidate gene for asthma
The discovery and role of ADAM33, a new candidate gene for asthma
Asthma is a complex disorder in which major genetic and environmental factors interact to initiate the disease and propagate it as a chronic relapsing disorder. Until recently, genetic factors implicated in the disease pathogenesis have been restricted to variants in known molecules involved in the inflammatory or remodelling pathways. This review discusses evidence for a new susceptibility gene for asthma, ADAM33, which was identified by positional cloning and shown to be selectively expressed in mesenchymal but not immune or inflammatory cells. ADAM33 belongs to a family of membrane–anchored metalloproteinases that also have fusagenic, adhesion and intracellular signalling properties. ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.
asthma, A Disintegrin and Metalloprotease 33 (ADAM33), genetics, epithelial–mesenchymal trophic unit, sheddase
1-12
Holloway, John W.
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Keith, Tim P.
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Davies, Donna E.
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Powell, Robert
ab373473-8f49-4d7b-80e6-8d3234c5250c
Haitchi, Hans-Michael
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Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
2004
Holloway, John W.
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Keith, Tim P.
a9d7a544-cc17-4cc7-a12f-71af7b6dfb70
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Powell, Robert
ab373473-8f49-4d7b-80e6-8d3234c5250c
Haitchi, Hans-Michael
68dadb29-305d-4236-884f-e9c93f4d78fe
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Holloway, John W., Keith, Tim P., Davies, Donna E., Powell, Robert, Haitchi, Hans-Michael and Holgate, Stephen T.
(2004)
The discovery and role of ADAM33, a new candidate gene for asthma.
Expert Reviews in Molecular Medicine, 6 (17), .
(doi:10.1017/S1462399404007963).
Abstract
Asthma is a complex disorder in which major genetic and environmental factors interact to initiate the disease and propagate it as a chronic relapsing disorder. Until recently, genetic factors implicated in the disease pathogenesis have been restricted to variants in known molecules involved in the inflammatory or remodelling pathways. This review discusses evidence for a new susceptibility gene for asthma, ADAM33, which was identified by positional cloning and shown to be selectively expressed in mesenchymal but not immune or inflammatory cells. ADAM33 belongs to a family of membrane–anchored metalloproteinases that also have fusagenic, adhesion and intracellular signalling properties. ADAM33 might play a key role in predisposing to the reduced lung function characteristic of asthma, possibly by influencing airway wall remodelling.
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Published date: 2004
Keywords:
asthma, A Disintegrin and Metalloprotease 33 (ADAM33), genetics, epithelial–mesenchymal trophic unit, sheddase
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Local EPrints ID: 27140
URI: http://eprints.soton.ac.uk/id/eprint/27140
ISSN: 1462-3994
PURE UUID: 09470e5f-40d7-42de-a973-28813684cdb8
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Date deposited: 26 Apr 2006
Last modified: 16 Mar 2024 03:29
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Author:
Tim P. Keith
Author:
Robert Powell
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