Thresholds of allergenic proteins in foods
Thresholds of allergenic proteins in foods
Threshold doses or Estimated Eliciting Doses (EEDs) represent an important new field of research in food allergy. Clinicians and regulators have embraced some toxicological concepts such as LOAEL and NOAEL and applied them to an area of significant clinical uncertainty and interest. The impact of intrinsic human factors (e.g., asthma and exercise) and extrinsic event factors (e.g., season, location and especially dose of allergen) on a future allergic reaction in the community needs to be considered carefully when interpreting results of clinical and research low-dose food challenges. The ongoing cooperation of food allergy research groups in medicine, food science and government will surely deliver results of the highest importance to the wider communities of allergology, food science and technology and the increasing number of allergic consumers.
anaphylaxis, allergy, thresholds, IgE, double-blind food challenge
152-156
Hourihane, Jonathan O.B.
5b470579-d353-411a-bbc5-76c6389ab7d7
Knulst, Andre C.
bfeb4534-8a53-4fe7-8584-a3c79db2e438
2005
Hourihane, Jonathan O.B.
5b470579-d353-411a-bbc5-76c6389ab7d7
Knulst, Andre C.
bfeb4534-8a53-4fe7-8584-a3c79db2e438
Hourihane, Jonathan O.B. and Knulst, Andre C.
(2005)
Thresholds of allergenic proteins in foods.
Toxicology and Applied Pharmacology, 207 (2 Supplement 1), .
(doi:10.1016/j.taap.2005.01.028).
Abstract
Threshold doses or Estimated Eliciting Doses (EEDs) represent an important new field of research in food allergy. Clinicians and regulators have embraced some toxicological concepts such as LOAEL and NOAEL and applied them to an area of significant clinical uncertainty and interest. The impact of intrinsic human factors (e.g., asthma and exercise) and extrinsic event factors (e.g., season, location and especially dose of allergen) on a future allergic reaction in the community needs to be considered carefully when interpreting results of clinical and research low-dose food challenges. The ongoing cooperation of food allergy research groups in medicine, food science and government will surely deliver results of the highest importance to the wider communities of allergology, food science and technology and the increasing number of allergic consumers.
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Published date: 2005
Additional Information:
Review Article
Proceedings of the 10th International Congress of Toxicology 11-15 July, 2004, Tampere, Finland: Living in a Safe Chemical World.
Keywords:
anaphylaxis, allergy, thresholds, IgE, double-blind food challenge
Identifiers
Local EPrints ID: 27149
URI: http://eprints.soton.ac.uk/id/eprint/27149
PURE UUID: 47e5f6d4-b3e8-4566-b379-6987c773a377
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Date deposited: 26 Apr 2006
Last modified: 15 Mar 2024 07:16
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Contributors
Author:
Jonathan O.B. Hourihane
Author:
Andre C. Knulst
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