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Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency

Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency
Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency
Peanut allergy is a severe and life-threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy.
0105-4538
536-537
Hourihane, J.O.
01ba1495-72e1-4522-b627-60a7d31aae20
Rhodes, H.L.
b1b7bc9c-9807-4f65-bd4d-9cb9cc12477a
Jones, A.M.
9f3a310d-f9d8-467f-bbc0-d210659ca7c4
Veys, P.
9ccba2d2-39a1-402a-a6e9-61b9476fe1e5
Connett, G.J.
55d5676c-90d8-46bf-a508-62eded276516
Hourihane, J.O.
01ba1495-72e1-4522-b627-60a7d31aae20
Rhodes, H.L.
b1b7bc9c-9807-4f65-bd4d-9cb9cc12477a
Jones, A.M.
9f3a310d-f9d8-467f-bbc0-d210659ca7c4
Veys, P.
9ccba2d2-39a1-402a-a6e9-61b9476fe1e5
Connett, G.J.
55d5676c-90d8-46bf-a508-62eded276516

Hourihane, J.O., Rhodes, H.L., Jones, A.M., Veys, P. and Connett, G.J. (2005) Resolution of peanut allergy following bone marrow transplantation for primary immunodeficiency. Allergy, 60 (4), 536-537. (doi:10.1111/j.1398-9995.2005.00752.x).

Record type: Article

Abstract

Peanut allergy is a severe and life-threatening form of food allergy. Treatments are being developed but the mainstays of current management remain avoidance of peanut and appropriate use of rescue medication. We report the case of a boy with peanut allergy who required a bone marrow transplant (BMT) for combined immunodeficiency. A food challenge, 2 years after transplant, showed that his peanut allergy had resolved. Allergic disorders constitute a form of immune deviation and while we do not advocate BMT as a treatment for peanut allergy, we believe this case provides an insight into the basic mechanisms involved in food allergy.

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Published date: 2005

Identifiers

Local EPrints ID: 27150
URI: http://eprints.soton.ac.uk/id/eprint/27150
ISSN: 0105-4538
PURE UUID: 332d5b93-414f-497c-9fda-5ae62179c36a
ORCID for G.J. Connett: ORCID iD orcid.org/0000-0003-1310-3239

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Date deposited: 25 Apr 2006
Last modified: 17 Dec 2019 01:24

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