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Antihistamines in rhinoconjunctivitis

Howarth, P. (2002) Antihistamines in rhinoconjunctivitis Clinical Allergy and Immunology, 17, pp. 179-220.

Record type: Article


In allergic rhinoconjunctivitis, histamine is known to contribute predominantly to nasal itch, sneeze, rhinorrhea, conjunctival itch, and lacrimation and these symptoms benefit most from H1-antihistamine therapy. The discovery in the early 1980s of nonsedating H1-receptor antagonists contributed dramatically to the more widespread acceptance of this mode of therapy. This also led to the undertaking of well-designed clinical trials that have added significantly to our understanding of allergic rhinitis. Oral treatment modifies both nasal and ocular symptoms and provides effective control throughout a 24-h period with once- or twice-daily medication. The advent of topical H1-receptor antagonists offers a wider choice of treatments and provides equal or greater efficacy with lower systemic bioavailability. While having a major impact on rhinoconjunctivitis symptoms, H1-antihistamines do not fully modify disease since histamine is not the only contributor to symptom generation in allergic rhinoconjunctivitis. While the search for oral H1-antihistamines with more widespread "antiallergic" activity continues, the currently available medications modify predominantly histamine-regulated events despite in vitro evidence of greater potential. The development of these new medications may be the next significant advance in this mode of treatment.

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Published date: 2002
Additional Information: Review Article


Local EPrints ID: 27152
ISSN: 1075-7910
PURE UUID: 6ff8b694-f929-4801-9756-330c531a4e85

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Date deposited: 26 Apr 2006
Last modified: 17 Jul 2017 16:05

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