The University of Southampton
University of Southampton Institutional Repository

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection

HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.
0036-8075
872-874
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Thio, Chloe L.
9bb90dbe-60a7-4574-b16a-33d7a3ecb07b
Martin, Maureen P.
f754a5fa-a475-425b-b0cb-9913a7afab14
Brooks, Collin R.
a9ae35ca-98a6-4e01-8336-859c98424b11
Gao, Xiaojiang
b62a02d2-1e1b-40c6-8afb-721a2ea851f8
Astemborski, Jacquie
75ec0057-6f26-4a4c-9ea2-206d08b0be65
Cheng, Jie
aba872b2-a455-4322-af50-56f07aeb4b55
Goedert, James J.
d28c5645-6f66-4763-8527-662cde9a8c13
Vlahov, David
a3cdbabb-d5a8-4ceb-aa76-9b07b44e1a2d
Hilgartner, Margaret
6f3ec82a-6db4-42b8-bcb2-d5240a815932
Cox, Steven
a73b4a07-2da9-48aa-98ef-fd21c4fa2de9
Little, Ann-Margeret
9254cf89-600b-4230-bb15-10b7d944c0c1
Alexander, Graeme J.
3373aaa7-0249-4edd-b88f-a63677f32bba
Cramp, Matthew E.
94034caa-fd63-48ef-bb7f-8f02f833bbce
O'Brien, Stephen J.
6e5e6920-9888-45e4-a194-69d1e0cc9201
Rosenberg, William M.
ac36bd93-2303-4a46-96f6-3daee7ec53b5
Thomas, David L.
e84d3756-82ad-47a9-9f99-5948f3b7e557
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Thio, Chloe L.
9bb90dbe-60a7-4574-b16a-33d7a3ecb07b
Martin, Maureen P.
f754a5fa-a475-425b-b0cb-9913a7afab14
Brooks, Collin R.
a9ae35ca-98a6-4e01-8336-859c98424b11
Gao, Xiaojiang
b62a02d2-1e1b-40c6-8afb-721a2ea851f8
Astemborski, Jacquie
75ec0057-6f26-4a4c-9ea2-206d08b0be65
Cheng, Jie
aba872b2-a455-4322-af50-56f07aeb4b55
Goedert, James J.
d28c5645-6f66-4763-8527-662cde9a8c13
Vlahov, David
a3cdbabb-d5a8-4ceb-aa76-9b07b44e1a2d
Hilgartner, Margaret
6f3ec82a-6db4-42b8-bcb2-d5240a815932
Cox, Steven
a73b4a07-2da9-48aa-98ef-fd21c4fa2de9
Little, Ann-Margeret
9254cf89-600b-4230-bb15-10b7d944c0c1
Alexander, Graeme J.
3373aaa7-0249-4edd-b88f-a63677f32bba
Cramp, Matthew E.
94034caa-fd63-48ef-bb7f-8f02f833bbce
O'Brien, Stephen J.
6e5e6920-9888-45e4-a194-69d1e0cc9201
Rosenberg, William M.
ac36bd93-2303-4a46-96f6-3daee7ec53b5
Thomas, David L.
e84d3756-82ad-47a9-9f99-5948f3b7e557
Carrington, Mary
0fd214c9-4cbc-4719-9d75-9997cd474bd8

Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, Cheng, Jie, Goedert, James J., Vlahov, David, Hilgartner, Margaret, Cox, Steven, Little, Ann-Margeret, Alexander, Graeme J., Cramp, Matthew E., O'Brien, Stephen J., Rosenberg, William M., Thomas, David L. and Carrington, Mary (2004) HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science, 305 (5685), 872-874. (doi:10.1126/science.1097670).

Record type: Article

Abstract

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human leukocyte antigen C group1 (HLA-C1) ligand directly influence resolution of hepatitis C virus (HCV) infection. This effect was observed in Caucasians and African Americans with expected low infectious doses of HCV but not in those with high-dose exposure, in whom the innate immune response is likely overwhelmed. The data strongly suggest that inhibitory NK cell interactions are important in determining antiviral immunity and that diminished inhibitory responses confer protection against HCV.

This record has no associated files available for download.

More information

Published date: August 2004

Identifiers

Local EPrints ID: 27203
URI: http://eprints.soton.ac.uk/id/eprint/27203
ISSN: 0036-8075
PURE UUID: 69db45e1-0174-4243-8c87-1c2d9d5b9469
ORCID for Salim I. Khakoo: ORCID iD orcid.org/0000-0002-4057-9091

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 03:25

Export record

Altmetrics

Contributors

Author: Salim I. Khakoo ORCID iD
Author: Chloe L. Thio
Author: Maureen P. Martin
Author: Collin R. Brooks
Author: Xiaojiang Gao
Author: Jacquie Astemborski
Author: Jie Cheng
Author: James J. Goedert
Author: David Vlahov
Author: Margaret Hilgartner
Author: Steven Cox
Author: Ann-Margeret Little
Author: Graeme J. Alexander
Author: Matthew E. Cramp
Author: Stephen J. O'Brien
Author: William M. Rosenberg
Author: David L. Thomas
Author: Mary Carrington

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×