The University of Southampton
University of Southampton Institutional Repository

Predicting persistent disease among children who wheeze during early life

Predicting persistent disease among children who wheeze during early life
Predicting persistent disease among children who wheeze during early life
This study sought to determine factors influencing the persistence of early life wheezing up to the age of 10 yrs and to create a score identifying those with the highest risk of persistent disease.
Children were seen at birth, 1, 2, 4 and 10 yrs in a whole population birth cohort study (n=1,456). Information was collected prospectively on wheeze prevalence and subjects were classified into wheezing phenotypes. Early life genetic and environmental risk factors were recorded and skin-prick testing (SPT) was performed at 4 yrs. Independently significant factors for persisting wheeze were identified at logistic regression and used to create a score for persistence.
Wheezing persistence from the first 4 yrs to the age of 10 yrs occurred in 37% of early life wheezers. Independent significance for persistence was associated with asthmatic family history, atopic SPT at 4 yrs and recurrent chest infections at 2 yrs, whilst recurrent nasal symptoms at 1 yr conferred reduced risk. A cumulative risk score using these factors identified wheezing persistence in 83% scoring 4 and transience in 80% scoring 0.
Thus, a combination of genetic predisposition, early life atopy and recurrent chest infections favours the persistence of early life wheezing. Risk scores using such knowledge could provide prognostic guidance on the outcome of early wheeze.
0903-1936
767-771
Kurukulaaratchy, R.J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, S.
79b68905-6033-4cf8-8a36-af956611f854
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958
Kurukulaaratchy, R.J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, S.
79b68905-6033-4cf8-8a36-af956611f854
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Arshad, S.H.
917e246d-2e60-472f-8d30-94b01ef28958

Kurukulaaratchy, R.J., Matthews, S., Holgate, S.T. and Arshad, S.H. (2003) Predicting persistent disease among children who wheeze during early life. European Respiratory Journal, 22 (5), 767-771. (doi:10.1183/09031936.03.00005903).

Record type: Article

Abstract

This study sought to determine factors influencing the persistence of early life wheezing up to the age of 10 yrs and to create a score identifying those with the highest risk of persistent disease.
Children were seen at birth, 1, 2, 4 and 10 yrs in a whole population birth cohort study (n=1,456). Information was collected prospectively on wheeze prevalence and subjects were classified into wheezing phenotypes. Early life genetic and environmental risk factors were recorded and skin-prick testing (SPT) was performed at 4 yrs. Independently significant factors for persisting wheeze were identified at logistic regression and used to create a score for persistence.
Wheezing persistence from the first 4 yrs to the age of 10 yrs occurred in 37% of early life wheezers. Independent significance for persistence was associated with asthmatic family history, atopic SPT at 4 yrs and recurrent chest infections at 2 yrs, whilst recurrent nasal symptoms at 1 yr conferred reduced risk. A cumulative risk score using these factors identified wheezing persistence in 83% scoring 4 and transience in 80% scoring 0.
Thus, a combination of genetic predisposition, early life atopy and recurrent chest infections favours the persistence of early life wheezing. Risk scores using such knowledge could provide prognostic guidance on the outcome of early wheeze.

Full text not available from this repository.

More information

Published date: 1 November 2003

Identifiers

Local EPrints ID: 27215
URI: http://eprints.soton.ac.uk/id/eprint/27215
ISSN: 0903-1936
PURE UUID: d1257a19-d4d7-44e0-a91a-343d665e72af
ORCID for R.J. Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 18 Feb 2021 16:54

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×