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Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function

Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function
Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function
Recent evidence suggests that impaired lung development is linked with diminished lung function and an increased risk of chronic obstructive airway disease in adulthood. To examine environmental influences on early lung development, we measured lung function in 131 normal-term infants aged 5–14 weeks. Adjusting for age at measurement, FEV at 0.4 seconds fell by 4.4% for each standard deviation decrease in birth weight (p = 0.047); when adjusted for FVC, FEV at 0.4 seconds was not related to birth weight but fell by 3.2% per standard deviation increase in infant weight gain (p = 0.001). Age- and sex-adjusted total respiratory system compliance fell by 7.0% per standard deviation decrease in birth weight (p < 0.001) but was not related to infant weight gain. In univariate analyses, age-adjusted forced expiratory flow at functional residual capacity was not related to birth weight, but decreased by 11.0% per standard deviation increase in infant weight gain (p = 0.007). The respiratory rate rose by 5.1% per standard deviation increase in infant weight gain (p = 0.001). Lung function measurements were not related to infant feeding. The observations suggest that lower rates of fetal growth and higher rates of early infancy weight gain are associated with impaired lung development.
infant, FEV, forced expiratory flow rates, lung function, weight gain
1073-449X
534-540
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Foreman, Claire T.
1c1d32d7-65cf-4e92-9858-8ed78e54fca1
Warner, John O.
50630e99-8486-4859-ade3-cd2c79c5a153
Gregson, Rachael K.
e1ffe9a0-b04c-4ba0-b2bb-596f8886019c
Clough, Joanne B.
34303b05-f47d-4e5d-8763-46628fbe1a8c
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Foreman, Claire T.
1c1d32d7-65cf-4e92-9858-8ed78e54fca1
Warner, John O.
50630e99-8486-4859-ade3-cd2c79c5a153
Gregson, Rachael K.
e1ffe9a0-b04c-4ba0-b2bb-596f8886019c
Clough, Joanne B.
34303b05-f47d-4e5d-8763-46628fbe1a8c

Lucas, Jane S., Inskip, Hazel M., Godfrey, Keith M., Foreman, Claire T., Warner, John O., Gregson, Rachael K. and Clough, Joanne B. (2004) Small size at birth and greater postnatal weight gain: relationships to diminished infant lung function. American Journal of Respiratory and Critical Care Medicine, 170 (5), 534-540. (doi:10.1164/rccm.200311-1583OC).

Record type: Article

Abstract

Recent evidence suggests that impaired lung development is linked with diminished lung function and an increased risk of chronic obstructive airway disease in adulthood. To examine environmental influences on early lung development, we measured lung function in 131 normal-term infants aged 5–14 weeks. Adjusting for age at measurement, FEV at 0.4 seconds fell by 4.4% for each standard deviation decrease in birth weight (p = 0.047); when adjusted for FVC, FEV at 0.4 seconds was not related to birth weight but fell by 3.2% per standard deviation increase in infant weight gain (p = 0.001). Age- and sex-adjusted total respiratory system compliance fell by 7.0% per standard deviation decrease in birth weight (p < 0.001) but was not related to infant weight gain. In univariate analyses, age-adjusted forced expiratory flow at functional residual capacity was not related to birth weight, but decreased by 11.0% per standard deviation increase in infant weight gain (p = 0.007). The respiratory rate rose by 5.1% per standard deviation increase in infant weight gain (p = 0.001). Lung function measurements were not related to infant feeding. The observations suggest that lower rates of fetal growth and higher rates of early infancy weight gain are associated with impaired lung development.

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More information

Published date: 2004
Keywords: infant, FEV, forced expiratory flow rates, lung function, weight gain

Identifiers

Local EPrints ID: 27240
URI: http://eprints.soton.ac.uk/id/eprint/27240
ISSN: 1073-449X
PURE UUID: 33e832d1-9a4d-490c-8fff-1f5318ec1bcb
ORCID for Jane S. Lucas: ORCID iD orcid.org/0000-0001-8701-9975
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 03:25

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Contributors

Author: Jane S. Lucas ORCID iD
Author: Hazel M. Inskip ORCID iD
Author: Claire T. Foreman
Author: John O. Warner
Author: Rachael K. Gregson
Author: Joanne B. Clough

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