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Oscillatory dynamics in a double activator motif

Oscillatory dynamics in a double activator motif
Oscillatory dynamics in a double activator motif
Biological oscillators, specially those that constitute the circadian clock, have been extensively modelled as coupled feedback loops of positive and negative elements in gene regulatory circuits. The presence of a negative feedback loop is a necessary condition for the onset of oscillations, and different mechanistic implementations have been modelled, such as transcriptional repression (such as CRY/PER down-regulating activation by CLOCK:BMAL1 in the mammalian clock) or by enhancing proteolysis. It is also a characteristic feature of transcriptional control in clock systems that conserved cis-regulatory sequences (such as E- and D-boxes) are competitively bound by transctiption factors. Using this feature, we propose a new duplicated autoregulated motif where competition for the same promoters by differentially activating transctiption factors drives oscillations.
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698

Dasmahapatra, Srinandan (2011) Oscillatory dynamics in a double activator motif. International Workshop on Computational Systems Biology (WCSB 2011). 06 - 08 Jun 2011.

Record type: Conference or Workshop Item (Paper)

Abstract

Biological oscillators, specially those that constitute the circadian clock, have been extensively modelled as coupled feedback loops of positive and negative elements in gene regulatory circuits. The presence of a negative feedback loop is a necessary condition for the onset of oscillations, and different mechanistic implementations have been modelled, such as transcriptional repression (such as CRY/PER down-regulating activation by CLOCK:BMAL1 in the mammalian clock) or by enhancing proteolysis. It is also a characteristic feature of transcriptional control in clock systems that conserved cis-regulatory sequences (such as E- and D-boxes) are competitively bound by transctiption factors. Using this feature, we propose a new duplicated autoregulated motif where competition for the same promoters by differentially activating transctiption factors drives oscillations.

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More information

Published date: June 2011
Additional Information: Event Dates: June 6-8, 2011
Venue - Dates: International Workshop on Computational Systems Biology (WCSB 2011), 2011-06-06 - 2011-06-08
Organisations: Southampton Wireless Group

Identifiers

Local EPrints ID: 272432
URI: https://eprints.soton.ac.uk/id/eprint/272432
PURE UUID: 1f8dbd76-e0b0-4be2-9efb-592e16082b3b

Catalogue record

Date deposited: 10 Jun 2011 11:08
Last modified: 18 Jul 2017 06:24

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