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Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae

Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae
Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae
Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae can lead to acute salpingitis, an inflammatory condition, which is a major cause of infertility. Challenge of explants of human FT with gonococci induced mRNA expression and protein secretion for the proinflammatory cytokines interleukin (IL)-1alpha, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) but not for granulocyte-macrophage colony-stimulating factor. In contrast, FT expression of IL-6 and of the cytokine receptors IL-6R, TNF receptor I (TNF-RI), and TNF-RII was constitutive and was not increased by gonococcal challenge. These studies suggest that several proinflammatory cytokines are likely to contribute to the cell and tissue damage observed in gonococcal salpingitis.
0019-9567
527-532
Maisey, Kevin
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Nardocci, Gino
af0c7d42-8d02-4783-a248-18f0cc10e2e7
Imarai, Monica
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Cardenas, Hugo
655f8130-647f-413a-8742-1b11d459e4c9
Rios, Miguel
943356c2-7c59-4347-a973-8a82a45b1027
Croxatto, Horacio B.
e05697a4-7076-4e02-932d-695e47a74b84
Heckels, John E.
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Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Velasquez, Luis A.
3a9da5d4-5091-4b16-9475-4e7e48f8d2f0
Maisey, Kevin
9deff4f4-c830-4335-8839-19d45f9a9d78
Nardocci, Gino
af0c7d42-8d02-4783-a248-18f0cc10e2e7
Imarai, Monica
600ac09a-b62d-4109-8f7d-4318e1628a7e
Cardenas, Hugo
655f8130-647f-413a-8742-1b11d459e4c9
Rios, Miguel
943356c2-7c59-4347-a973-8a82a45b1027
Croxatto, Horacio B.
e05697a4-7076-4e02-932d-695e47a74b84
Heckels, John E.
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Velasquez, Luis A.
3a9da5d4-5091-4b16-9475-4e7e48f8d2f0

Maisey, Kevin, Nardocci, Gino, Imarai, Monica, Cardenas, Hugo, Rios, Miguel, Croxatto, Horacio B., Heckels, John E., Christodoulides, Myron and Velasquez, Luis A. (2003) Expression of proinflammatory cytokines and receptors by human fallopian tubes in organ culture following challenge with Neisseria gonorrhoeae. Infection and Immunity, 71 (1), 527-532. (doi:10.1128/IAI.71.1.527-532.2003).

Record type: Article

Abstract

Infection of the Fallopian tubes (FT) by Neisseria gonorrhoeae can lead to acute salpingitis, an inflammatory condition, which is a major cause of infertility. Challenge of explants of human FT with gonococci induced mRNA expression and protein secretion for the proinflammatory cytokines interleukin (IL)-1alpha, IL-1beta, and tumor necrosis factor alpha (TNF-alpha) but not for granulocyte-macrophage colony-stimulating factor. In contrast, FT expression of IL-6 and of the cytokine receptors IL-6R, TNF receptor I (TNF-RI), and TNF-RII was constitutive and was not increased by gonococcal challenge. These studies suggest that several proinflammatory cytokines are likely to contribute to the cell and tissue damage observed in gonococcal salpingitis.

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Published date: 2003

Identifiers

Local EPrints ID: 27247
URI: http://eprints.soton.ac.uk/id/eprint/27247
ISSN: 0019-9567
PURE UUID: 8fa5b03b-5d64-44d4-b471-049066caddf2
ORCID for Myron Christodoulides: ORCID iD orcid.org/0000-0002-9663-4731

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Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 02:38

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Contributors

Author: Kevin Maisey
Author: Gino Nardocci
Author: Monica Imarai
Author: Hugo Cardenas
Author: Miguel Rios
Author: Horacio B. Croxatto
Author: John E. Heckels
Author: Luis A. Velasquez

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