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Transcriptional regulation of hepatic stellate cell activation

Transcriptional regulation of hepatic stellate cell activation
Transcriptional regulation of hepatic stellate cell activation
The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the HSC genome. The considerable advances that have been made in the past five years into the mechanisms by which specific families of transcription factors regulate the profibrogenic characteristics of the activated HSC are reviewed.
transcriptional regulation, hepatic stellate cell, hepatic stellate cell activation, liver fibrosis
0017-5749
891-896
Mann, D.A.
54e772bb-f94f-4485-98c8-b2339a929d86
Smart, D.E.
3fc82f4e-727a-4f79-96ee-8c80765cad59
Mann, D.A.
54e772bb-f94f-4485-98c8-b2339a929d86
Smart, D.E.
3fc82f4e-727a-4f79-96ee-8c80765cad59

Mann, D.A. and Smart, D.E. (2002) Transcriptional regulation of hepatic stellate cell activation. Gut, 50 (6), 891-896.

Record type: Article

Abstract

The hepatic stellate cell (HSC) is now well established as the key cellular element involved in the development of hepatic fibrosis and because of this there is considerable interest in establishing the molecular events that trigger and perpetuate HSC activation. HSC activation at the level of gene transcription requires the coordinated activity of several key transcriptional regulators of the HSC genome. The considerable advances that have been made in the past five years into the mechanisms by which specific families of transcription factors regulate the profibrogenic characteristics of the activated HSC are reviewed.

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More information

Published date: 2002
Additional Information: Review Article
Keywords: transcriptional regulation, hepatic stellate cell, hepatic stellate cell activation, liver fibrosis

Identifiers

Local EPrints ID: 27251
URI: http://eprints.soton.ac.uk/id/eprint/27251
ISSN: 0017-5749
PURE UUID: c7ff3fee-7f86-4536-ad3a-988a023484e4

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Date deposited: 28 Apr 2006
Last modified: 08 Jan 2022 15:51

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Contributors

Author: D.A. Mann
Author: D.E. Smart

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