Dietary prevention of allergic diseases in infants and small children. Part II: Evaluation of methods in allergy prevention studies and sensitization markers. Definitions and diagnostic criteria of allergic diseases

Muraro, A., Dreborg, S., Halken, S., Høst, A., Niggemann, B., Aalberse, R., Arshad, S.H., Berg, A.v., Carlsen, K.-H., Duschén, K., Eigenmann, P., Hill, D., Jones, C., Mellon, M., Oldeus, G., Oranje, A., Pascual, C., Prescott, S., Sampson, H., Svartengren, M., Vandenplas, Y., Wahn, U., Warner, J.A., Warner, J.O., Wickman, M. and Zeiger, R.S. (2004) Dietary prevention of allergic diseases in infants and small children. Part II: Evaluation of methods in allergy prevention studies and sensitization markers. Definitions and diagnostic criteria of allergic diseases. Pediatric Allergy and Immunology, 15 (3), 196-205. (doi:10.1111/j.1399-3038.2004.00128.x).

Abstract

The role of primary prevention of allergic diseases has been a matter of debate for the last 40 years. In order to shed some light into this issue a group of experts of the Section of Pediatrics EAACI critically reviewed the existing literature on the subject. The design of observational and interventional studies was evaluated with relevance to the important factors influencing outcome of studies on allergy development/prevention. In this analysis the statements of evidence as defined by WHO were applied. Best evidence of recommendations are those fulfilling the criteria for statements category 1 and 2 and grade of recommendations A and B as proposed by WHO. This survey include target group for dietary prevention and methods and diagnostic criteria of atopic dermatitis, asthma and food allergy for prevention studies.

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