Towards molecular computing: co-development of microfluidic devices and chemical reaction media

King, Philip, Corsi, Josephine C., Pan, Ben-Hong, Morgan, Hywel, de Planque, Maurits R.R. and Zauner, Klaus-Peter (2012) Towards molecular computing: co-development of microfluidic devices and chemical reaction media Biosystems, 109, (1), pp. 18-23. (doi:10.1016/j.biosystems.2012.01.003).


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Microfluidics provides a powerful technology for both the production of molecular computing components and for the implementation of molecular computing architectures. The potential commercial applications of microfluidics drive rapid progress in this field—but at the same time focus interest on materials that are compatible with physiological aqueous conditions. For engineering applications that consider a broader range of physico-chemical conditions the narrow set of established materials for microfluidics can be a challenge. As a consequence of the large surface to volume ratio inherent in microfluidic technology the material of the device can greatly affect the chemistry in the channels of the device. In practice it is necessary to co-develop the chemical medium to be used in the device together with the microfluidic devices. We describe this process for a molecular computing architecture that makes use of excitable lipid-coated droplets of Belousov–Zhabotinsky reaction medium as its active processing components. We identify fluoropolymers with low melting temperature as a suitable substrate for microfluidics to be used in conjunction with Belousov–Zhabotinsky droplets in decane.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.biosystems.2012.01.003
ISSNs: 0303-2647 (print)
Related URLs:
Organisations: Nanoelectronics and Nanotechnology, Agents, Interactions & Complexity
ePrint ID: 273062
Date :
Date Event
4 January 2012Accepted/In Press
9 June 2012Published
Date Deposited: 13 Dec 2011 09:58
Last Modified: 17 Apr 2017 17:34
Further Information:Google Scholar

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