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Haemochromatosis: the need for an agreed case definition

Haemochromatosis: the need for an agreed case definition
Haemochromatosis: the need for an agreed case definition
We were pleased to read the editorial that accompanied the publication of our study. We would like to address one comment that was made. Professor Olynyk queried our allocation of patients to treatment. We failed to explain clearly that any individuals with ferritin levels above the upper limits of normal who were not offered venesection were monitored with repeat ferritin and transferrin saturation at 3 months, followed by a recommendation to their family doctor for further monitoring or referral for treatment should there be evidence of iron accumulation. This strategy reflects the current clinical uncertainty concerning the natural history of iron overload in patients such as these. Despite attempts to reach consensus over the clinical case definition of haemochromatosis further clinical research is required to determine the prognosis of HFE mutations and iron overload. We would urge clinicians and researchers in this area to consider this problem.
0168-8278
911-912
Patch, Christine
b25a4961-4115-4516-ba1b-36c576736b06
Roderick, Paul
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Rosenberg, William
cea47565-06a3-4622-931c-aa5a7686865c
Patch, Christine
b25a4961-4115-4516-ba1b-36c576736b06
Roderick, Paul
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Rosenberg, William
cea47565-06a3-4622-931c-aa5a7686865c

Patch, Christine, Roderick, Paul and Rosenberg, William (2005) Haemochromatosis: the need for an agreed case definition. Journal of Hepatology, 43 (5), 911-912. (doi:10.1016/j.jhep.2005.09.001).

Record type: Article

Abstract

We were pleased to read the editorial that accompanied the publication of our study. We would like to address one comment that was made. Professor Olynyk queried our allocation of patients to treatment. We failed to explain clearly that any individuals with ferritin levels above the upper limits of normal who were not offered venesection were monitored with repeat ferritin and transferrin saturation at 3 months, followed by a recommendation to their family doctor for further monitoring or referral for treatment should there be evidence of iron accumulation. This strategy reflects the current clinical uncertainty concerning the natural history of iron overload in patients such as these. Despite attempts to reach consensus over the clinical case definition of haemochromatosis further clinical research is required to determine the prognosis of HFE mutations and iron overload. We would urge clinicians and researchers in this area to consider this problem.

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Published date: 2005

Identifiers

Local EPrints ID: 27316
URI: http://eprints.soton.ac.uk/id/eprint/27316
ISSN: 0168-8278
PURE UUID: 1bc51725-70ed-4de5-a9ff-d86996e44b62
ORCID for Paul Roderick: ORCID iD orcid.org/0000-0001-9475-6850

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 08 Jan 2022 02:41

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Contributors

Author: Christine Patch
Author: Paul Roderick ORCID iD
Author: William Rosenberg

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