The University of Southampton
University of Southampton Institutional Repository

Can Simpson's Paradox explain co-operation in Pseudomonas aeruginosa biofilms?

Record type: Article

Co-operative behaviours, such as the production of public goods, are commonly displayed by bacteria in biofilms and can enhance their ability to survive in environmental or clinical settings. Non-cooperative cheats commonly arise and should, theoretically, disrupt co-operative behaviour. Its stability therefore requires explanation, but no mechanisms to supress cheating within biofilms have yet been demonstrated experimentally. Theoretically, repeated aggregation into groups, interleaved with dispersal and remixing, can increase cooperation via a ‘Simpson’s Paradox’; an increase in the global proportion of co-operators despite a decrease in within-group proportions, via differential growth of groups. We hypothesise that microcolony formation and dispersal can produce a Simpson’s paradox and may explain bacterial cooperation in biofilms. Using the production of siderophores in Pseudomonas aeruginosa as our model system for co-operation, we use well-documented co-operator and siderophore-deficient cheat strains to measure the frequency of cooperating and cheating individuals in-situ within microcolony structures. We detected significant within-type negative density-dependant effects which vary over microcolony development. However, we find no evidence of Simpson’s paradox. Instead we see clear within-microcolony spatial structure (cheats occupying the interior portions of microcolonies) that may violate the assumption required for Simpson’s paradox that group members share equally in the public good

Full text not available from this repository.

Citation

Penn, Alexandra, S., Conibear, Tim C.R., Watson, Richard, A., Kraaijeveld, Alex R. and Webb, Jeremy, S. (2012) Can Simpson's Paradox explain co-operation in Pseudomonas aeruginosa biofilms? [in special issue: Biofilms II] FEMS Immunology & Medical Microbiology, 65, (2), pp. 226-235. (doi:10.1111/j.1574-695X.2012.00970.x).

More information

e-pub ahead of print date: 23 April 2012
Published date: July 2012
Organisations: Agents, Interactions & Complexity, Centre for Biological Sciences

Identifiers

Local EPrints ID: 273199
URI: http://eprints.soton.ac.uk/id/eprint/273199
ISSN: 0928-8244
PURE UUID: 67930def-8f13-460d-a09f-0acd7559ea55
ORCID for Alex R. Kraaijeveld: ORCID iD orcid.org/0000-0002-8543-2640

Catalogue record

Date deposited: 07 Feb 2012 10:49
Last modified: 18 Jul 2017 06:15

Export record

Altmetrics

Contributors

Author: Alexandra, S. Penn
Author: Tim C.R. Conibear
Author: Jeremy, S. Webb

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×