Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease
Adenosine is a purine nucleoside which mediates a variety of cellular responses relevant to asthma and COPD through interaction with specific receptors. Administration of adenosine by inhalation to patients with asthma and COPD is known to cause concentration related bronchoconstriction. Responses elicited by this purine derivative in asthma and COPD should not be considered as a mere reflection of non-specific airways hyperresponsiveness. Evaluation of airways responsiveness by adenosine induced bronchoconstriction may be valuable in differentiating asthma from COPD, monitoring of anti-inflammatory treatment in asthma, surveying disease progression, and assessing disease activity in relation to allergic airways inflammation.
adenosine, bronchial hyperresponsiveness, asthma, chronic obstructive pulmonary disease
649-654
Polosa, R.
34c9ef10-2fea-44a4-9521-63098d4c2571
Rorke, S.
ca4b3d19-8862-40e7-8f33-b20da825b08d
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
2002
Polosa, R.
34c9ef10-2fea-44a4-9521-63098d4c2571
Rorke, S.
ca4b3d19-8862-40e7-8f33-b20da825b08d
Holgate, S.T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Polosa, R., Rorke, S. and Holgate, S.T.
(2002)
Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease.
Thorax, 57 (7), .
(doi:10.1136/thorax.57.7.649).
Abstract
Adenosine is a purine nucleoside which mediates a variety of cellular responses relevant to asthma and COPD through interaction with specific receptors. Administration of adenosine by inhalation to patients with asthma and COPD is known to cause concentration related bronchoconstriction. Responses elicited by this purine derivative in asthma and COPD should not be considered as a mere reflection of non-specific airways hyperresponsiveness. Evaluation of airways responsiveness by adenosine induced bronchoconstriction may be valuable in differentiating asthma from COPD, monitoring of anti-inflammatory treatment in asthma, surveying disease progression, and assessing disease activity in relation to allergic airways inflammation.
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Published date: 2002
Keywords:
adenosine, bronchial hyperresponsiveness, asthma, chronic obstructive pulmonary disease
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Local EPrints ID: 27331
URI: http://eprints.soton.ac.uk/id/eprint/27331
ISSN: 0040-6376
PURE UUID: 6fca2f8b-10fe-4082-a232-e1fe4a24c0a2
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Date deposited: 27 Apr 2006
Last modified: 15 Mar 2024 07:17
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Author:
R. Polosa
Author:
S. Rorke
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