Pesticide residue analysis and its relationship to hazard characterisation (ADI/ARfD) and intake estimations (NEDI/NESTI)
Pesticide residue analysis and its relationship to hazard characterisation (ADI/ARfD) and intake estimations (NEDI/NESTI)
Over 800 pesticides are currently approved for use in one or more EU countries. The maximum residue levels (MRL) for agricultural pesticides are derived from field trials conducted under good agricultural practice (GAP). The MRL is a legally enforceable limit related to GAP. The results from field trials would only be used to establish MRLs if the estimated intake of residues did not exceed the acceptable daily intake (ADI) or acute reference dose (ARfD). However, the MRL is not linked to the ADI or ARfD, and could result in intakes considerably below the ADI/ARfD. This disconnection between hazard characterisation (ADI/ARfD) and potential exposure assessment (MRL) means that risk characterisation of pesticide residues is less transparent than for other chemicals present in human food. Residue levels at or below the MRL would not give intakes that exceed the ADI/ARfD but, despite this, there is public concern over such residues. Residue levels above the MRL have to be analysed on a case-by-case basis to determine if the intake could exceed the health-based limits. Other causes of public concern, such as the presence of multiple residues, are currently under investigation.
maximum residue level, agricultural pesticide, acceptable daily intake, acute reference dose, pesticide intake
1073-1082
Renwick, Andrew G.
3a210ca8-de23-4dae-aa6c-c853a1651d19
2002
Renwick, Andrew G.
3a210ca8-de23-4dae-aa6c-c853a1651d19
Renwick, Andrew G.
(2002)
Pesticide residue analysis and its relationship to hazard characterisation (ADI/ARfD) and intake estimations (NEDI/NESTI).
Pest Management Science, 58 (10), .
(doi:10.1002/ps.544).
Abstract
Over 800 pesticides are currently approved for use in one or more EU countries. The maximum residue levels (MRL) for agricultural pesticides are derived from field trials conducted under good agricultural practice (GAP). The MRL is a legally enforceable limit related to GAP. The results from field trials would only be used to establish MRLs if the estimated intake of residues did not exceed the acceptable daily intake (ADI) or acute reference dose (ARfD). However, the MRL is not linked to the ADI or ARfD, and could result in intakes considerably below the ADI/ARfD. This disconnection between hazard characterisation (ADI/ARfD) and potential exposure assessment (MRL) means that risk characterisation of pesticide residues is less transparent than for other chemicals present in human food. Residue levels at or below the MRL would not give intakes that exceed the ADI/ARfD but, despite this, there is public concern over such residues. Residue levels above the MRL have to be analysed on a case-by-case basis to determine if the intake could exceed the health-based limits. Other causes of public concern, such as the presence of multiple residues, are currently under investigation.
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Published date: 2002
Keywords:
maximum residue level, agricultural pesticide, acceptable daily intake, acute reference dose, pesticide intake
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Local EPrints ID: 27353
URI: http://eprints.soton.ac.uk/id/eprint/27353
ISSN: 1526-4998
PURE UUID: a950741e-6893-4429-8a5f-54bfdaf5ec71
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Date deposited: 27 Apr 2006
Last modified: 12 Nov 2024 17:59
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Author:
Andrew G. Renwick
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