The safety testing of amino acids
The safety testing of amino acids
The risk assessment of compounds added to foods or taken as supplements is usually based on hazard characterization studies performed in animal test species. A large default uncertainty factor, or margin or exposure, is usually required to allow for possible species differences and human variability in the toxicokinetics and toxicodynamics of the compound. The development of biomarkers offers the potential to rationalize the risk assessment of amino acids, and to refine the extrapolation of data from animals to humans. The use of high resolution nuclear magnetic resonance spectroscopy applied to readily accessible biological fluids, such as urine and plasma, offers great potential for the identification of toxicologically relevant biomarkers in animal studies that can then be applied to studies in humans.
amino acids, risk assessment, biomarkers, metabonomics, toxicokinetics
2031S-2033S
Renwick, Andrew G.
3a210ca8-de23-4dae-aa6c-c853a1651d19
2003
Renwick, Andrew G.
3a210ca8-de23-4dae-aa6c-c853a1651d19
Renwick, Andrew G.
(2003)
The safety testing of amino acids.
Journal of Nutrition, 133 (6 Supplement 1), .
Abstract
The risk assessment of compounds added to foods or taken as supplements is usually based on hazard characterization studies performed in animal test species. A large default uncertainty factor, or margin or exposure, is usually required to allow for possible species differences and human variability in the toxicokinetics and toxicodynamics of the compound. The development of biomarkers offers the potential to rationalize the risk assessment of amino acids, and to refine the extrapolation of data from animals to humans. The use of high resolution nuclear magnetic resonance spectroscopy applied to readily accessible biological fluids, such as urine and plasma, offers great potential for the identification of toxicologically relevant biomarkers in animal studies that can then be applied to studies in humans.
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Published date: 2003
Keywords:
amino acids, risk assessment, biomarkers, metabonomics, toxicokinetics
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Local EPrints ID: 27355
URI: http://eprints.soton.ac.uk/id/eprint/27355
ISSN: 0022-3166
PURE UUID: f2731aca-83d1-4849-aebe-81c918a0a055
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Date deposited: 27 Apr 2006
Last modified: 08 Jan 2022 06:51
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Author:
Andrew G. Renwick
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