On the generation of allergic airway diseases: from GM-CSF to Kyoto
On the generation of allergic airway diseases: from GM-CSF to Kyoto
The sharp increase in the prevalence of asthma over the past three decades suggests an important contribution of environmental factors in the generation of this disease, and compels a search for molecular pathways by which such factors could facilitate Th2 immune-inflammatory airway responses; granulocyte–macrophage colony-stimulating factor (GM-CSF) might be one such signal. In this review, we appraise the evidence with respect to the presence of GM-CSF in asthma, the roles played by GM-CSF in these immune responses and environmental triggers that can induce GM-CSF expression. Further, we propose a paradigm that unites these divergent observations, and postulate that GM-CSF produced in response to environmental agents can establish an airway microenvironment that promotes the initiation, influences the evolution and supports the maintenance of an aeroallergen-specific adaptive Th2 immune response.
Exposure to certain environmental agents can trigger the expression of GM-CSF in the airways, which might in part be responsible for Th2-mediated allergic asthma. Could this partly explain the increase in asthma prevalence in the West?
GM-CSF, dendritic cells, asthma, Th2 immune responses, Koch's postulates, pollution, allergen, epithelial cells
396-402
Ritz, Stacey A.
3238ca2a-210a-41e7-babb-aa2630a1da93
Stampfli, Martin R.
fef637df-f9e9-41eb-87cb-fc02bb0319c0
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Jordana, Manel
731a00c1-2ace-4d63-b0e1-7e1013616d71
2002
Ritz, Stacey A.
3238ca2a-210a-41e7-babb-aa2630a1da93
Stampfli, Martin R.
fef637df-f9e9-41eb-87cb-fc02bb0319c0
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Jordana, Manel
731a00c1-2ace-4d63-b0e1-7e1013616d71
Ritz, Stacey A., Stampfli, Martin R., Davies, Donna E., Holgate, Stephen T. and Jordana, Manel
(2002)
On the generation of allergic airway diseases: from GM-CSF to Kyoto.
Trends in Immunology, 23 (8), .
(doi:10.1016/S1471-4906(02)02278-0).
Abstract
The sharp increase in the prevalence of asthma over the past three decades suggests an important contribution of environmental factors in the generation of this disease, and compels a search for molecular pathways by which such factors could facilitate Th2 immune-inflammatory airway responses; granulocyte–macrophage colony-stimulating factor (GM-CSF) might be one such signal. In this review, we appraise the evidence with respect to the presence of GM-CSF in asthma, the roles played by GM-CSF in these immune responses and environmental triggers that can induce GM-CSF expression. Further, we propose a paradigm that unites these divergent observations, and postulate that GM-CSF produced in response to environmental agents can establish an airway microenvironment that promotes the initiation, influences the evolution and supports the maintenance of an aeroallergen-specific adaptive Th2 immune response.
Exposure to certain environmental agents can trigger the expression of GM-CSF in the airways, which might in part be responsible for Th2-mediated allergic asthma. Could this partly explain the increase in asthma prevalence in the West?
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Published date: 2002
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Opinion
Keywords:
GM-CSF, dendritic cells, asthma, Th2 immune responses, Koch's postulates, pollution, allergen, epithelial cells
Identifiers
Local EPrints ID: 27370
URI: http://eprints.soton.ac.uk/id/eprint/27370
ISSN: 1471-4906
PURE UUID: 3dfc190c-44d1-4188-af49-49c92021c4b4
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Date deposited: 27 Apr 2006
Last modified: 16 Mar 2024 02:34
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Author:
Stacey A. Ritz
Author:
Martin R. Stampfli
Author:
Manel Jordana
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