Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease
Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease
The traditional viewpoint that inflammation, owing to a genetic T-helper type 2 (Th2)-directed imbalance, is the cause of allergic rhinitis has meant that the potential coexistence of other genetic defects and the relevance of any airway remodelling changes to disease pathogenesis and persistence have received scant attention, and as such remain controversial areas. This is particularly so in view of the limited published work in this field, which has so far reported markedly conflicting findings. This review endeavours to outline what is known about the nature of the remodelling response within the upper airway in allergic rhinitis, in addition to highlighting specific areas where further research is warranted.
1629-1633
Salib, R.J.
962f24b6-1828-47e7-9827-4a627c63b18b
Howarth, P.H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
2003
Salib, R.J.
962f24b6-1828-47e7-9827-4a627c63b18b
Howarth, P.H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Salib, R.J. and Howarth, P.H.
(2003)
Remodelling of the upper airways in allergic rhinitis: is it a feature of the disease.
Clinical & Experimental Allergy, 33 (12), .
(doi:10.1111/j.1365-2222.2003.01828.x).
Abstract
The traditional viewpoint that inflammation, owing to a genetic T-helper type 2 (Th2)-directed imbalance, is the cause of allergic rhinitis has meant that the potential coexistence of other genetic defects and the relevance of any airway remodelling changes to disease pathogenesis and persistence have received scant attention, and as such remain controversial areas. This is particularly so in view of the limited published work in this field, which has so far reported markedly conflicting findings. This review endeavours to outline what is known about the nature of the remodelling response within the upper airway in allergic rhinitis, in addition to highlighting specific areas where further research is warranted.
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Published date: 2003
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Local EPrints ID: 27397
URI: http://eprints.soton.ac.uk/id/eprint/27397
ISSN: 0954-7894
PURE UUID: 5bc41246-1741-462a-9ef3-b6f7f0b3367f
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Date deposited: 25 Apr 2006
Last modified: 15 Mar 2024 07:18
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R.J. Salib
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