Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo
Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo
Endobronchial ultrasound (EBUS) allows identification of airway wall structures and could potentially be utilised for in vivo studies of airway thickening in asthma. The present study investigated whether inflation of the fluid-filled balloon sheath over the transducer (necessary to provide sonic coupling with the airway wall) influenced in vitro measurements. In vivo comparability of EBUS with high resolution computed tomography scanning (HRCT), an established method for measuring wall thickness, was determined in control subjects.
The airway diameter and wall thickness were studied using EBUS in 24 cartilaginous airways obtained from four sheep, before and after balloon sheath inflation during immersion in saline. To assess EBUS versus HRCT comparability of airway measures in vivo, 12 control subjects underwent imaging of the posterior basal bronchus of the right lower lobe by both techniques. Intra- and interobserver agreement were also assessed.
Results with and without the balloon sheath gave comparable measures of airway internal diameter and wall thickness in vitro. Statistical analysis showed agreement between EBUS and HRCT, and intra- and interobserver variability in vivo.
The current study concludes that endobronchial ultrasound, which does not present a radiation risk, could be utilised in the in vivo study of cartilaginous airway wall remodelling in respiratory diseases, such as asthma.
813-817
Shaw, T.J.
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Wakely, S.L.
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Peebles, C.R.
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Mehta, R.L.
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Turner, J.M.
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Wilson, S.J.
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Howarth, P.H.
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2004
Shaw, T.J.
ac1c32aa-5c9a-4434-ac7d-c93feb1f7385
Wakely, S.L.
87282e68-f758-411a-b4bf-59c04fab3bcd
Peebles, C.R.
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Mehta, R.L.
df063eb1-a3c5-4fdb-8620-152a1de20875
Turner, J.M.
bd0ab138-92f7-4158-9ee5-18a4f4568ccd
Wilson, S.J.
21c6875d-6870-441b-ae7a-603562a646b8
Howarth, P.H.
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Shaw, T.J., Wakely, S.L., Peebles, C.R., Mehta, R.L., Turner, J.M., Wilson, S.J. and Howarth, P.H.
(2004)
Endobronchial ultrasound to assess airway wall thickening: validation in vitro and in vivo.
European Respiratory Journal, 23 (6), .
(doi:10.1183/09031936.04.00119904).
Abstract
Endobronchial ultrasound (EBUS) allows identification of airway wall structures and could potentially be utilised for in vivo studies of airway thickening in asthma. The present study investigated whether inflation of the fluid-filled balloon sheath over the transducer (necessary to provide sonic coupling with the airway wall) influenced in vitro measurements. In vivo comparability of EBUS with high resolution computed tomography scanning (HRCT), an established method for measuring wall thickness, was determined in control subjects.
The airway diameter and wall thickness were studied using EBUS in 24 cartilaginous airways obtained from four sheep, before and after balloon sheath inflation during immersion in saline. To assess EBUS versus HRCT comparability of airway measures in vivo, 12 control subjects underwent imaging of the posterior basal bronchus of the right lower lobe by both techniques. Intra- and interobserver agreement were also assessed.
Results with and without the balloon sheath gave comparable measures of airway internal diameter and wall thickness in vitro. Statistical analysis showed agreement between EBUS and HRCT, and intra- and interobserver variability in vivo.
The current study concludes that endobronchial ultrasound, which does not present a radiation risk, could be utilised in the in vivo study of cartilaginous airway wall remodelling in respiratory diseases, such as asthma.
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Published date: 2004
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Local EPrints ID: 27421
URI: http://eprints.soton.ac.uk/id/eprint/27421
ISSN: 0903-1936
PURE UUID: 176b8047-9592-4cc3-9e33-a95dce39de54
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Date deposited: 26 Apr 2006
Last modified: 15 Mar 2024 07:18
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Author:
T.J. Shaw
Author:
S.L. Wakely
Author:
C.R. Peebles
Author:
R.L. Mehta
Author:
J.M. Turner
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