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The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics

The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics
The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics

In a recent placebo-controlled study in mild atopic asthmatics, we observed a significant decrease in eosinophils in the bronchial submucosa, after 2 months oftreatment with inhaled formoterol and budesonide. Biopsy material from each treatment group; formoterol (24 microg bid), budesonide (400 microg b. i. d.) and placebo has been further assessed to investigatethe role of Th-2 cytokines by immunohistochemistry using Mabs to eosinophils as an index of inflammation, IL-4 and IL-5. Treatment with formoterol significantly reduced the number of eosinophils (EG2+) in the submucosa and epithelium, but this was not paralleled by changes in cytokine immunoreactivity In contrast, treatment with budesonide significantly reduced both the number of eosinophils (EG2+) and immunoreactivity for IL-4 and IL-5 in the submucosa. Thus, while budesonide has effects on cytokines involved in eosinophil recruitmentthis explanation does not apply tothe eosinopaenia observed with the long-acting beta2 adrenoreceptor agonist formoterol.

1021-1025
Wallin, A.
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Sandström, T.
d3d026b6-08f7-4c4b-acc4-9c621390af69
Cioppa, G.D.
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Holgate, S.
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Wilson, S.
21c6875d-6870-441b-ae7a-603562a646b8
Wallin, A.
e1d92e81-9f98-4c78-9051-172dcdec1b75
Sandström, T.
d3d026b6-08f7-4c4b-acc4-9c621390af69
Cioppa, G.D.
6d6ccdc3-c19a-4f61-a15d-6c9921261abf
Holgate, S.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Wilson, S.
21c6875d-6870-441b-ae7a-603562a646b8

Wallin, A., Sandström, T., Cioppa, G.D., Holgate, S. and Wilson, S. (2002) The effects of regular inhaled formoterol and budesonide on preformed Th-2 cytokines in mild asthmatics. Respiratory Medicine, 96 (12), 1021-1025. (doi:10.1053/rmed.2002.1388).

Record type: Article

Abstract

In a recent placebo-controlled study in mild atopic asthmatics, we observed a significant decrease in eosinophils in the bronchial submucosa, after 2 months oftreatment with inhaled formoterol and budesonide. Biopsy material from each treatment group; formoterol (24 microg bid), budesonide (400 microg b. i. d.) and placebo has been further assessed to investigatethe role of Th-2 cytokines by immunohistochemistry using Mabs to eosinophils as an index of inflammation, IL-4 and IL-5. Treatment with formoterol significantly reduced the number of eosinophils (EG2+) in the submucosa and epithelium, but this was not paralleled by changes in cytokine immunoreactivity In contrast, treatment with budesonide significantly reduced both the number of eosinophils (EG2+) and immunoreactivity for IL-4 and IL-5 in the submucosa. Thus, while budesonide has effects on cytokines involved in eosinophil recruitmentthis explanation does not apply tothe eosinopaenia observed with the long-acting beta2 adrenoreceptor agonist formoterol.

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Published date: December 2002
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 27470
URI: http://eprints.soton.ac.uk/id/eprint/27470
PURE UUID: 4550a09f-1d9d-4c14-a946-7a84f43dfc64
ORCID for S. Wilson: ORCID iD orcid.org/0000-0003-1305-8271

Catalogue record

Date deposited: 28 Apr 2006
Last modified: 15 Mar 2024 07:18

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Contributors

Author: A. Wallin
Author: T. Sandström
Author: G.D. Cioppa
Author: S. Holgate
Author: S. Wilson ORCID iD

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