Hanging in the balance: KIR and their role in disease
Hanging in the balance: KIR and their role in disease
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. These findings together with the observation that several of these genes have human leukocyte antigen (HLA) class I ligands, have led to a flurry of investigation into how KIR participate in viral infections, autoimmune diseases and malignancies. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration.
226-240
Williams, Anthony P.
9dd1e3e0-056f-4014-b8ba-a68b21b90def
Bateman, Andrew R.
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Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
2005
Williams, Anthony P.
9dd1e3e0-056f-4014-b8ba-a68b21b90def
Bateman, Andrew R.
a851558d-8b9b-4020-b148-a239c2b26815
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Williams, Anthony P., Bateman, Andrew R. and Khakoo, Salim I.
(2005)
Hanging in the balance: KIR and their role in disease.
Molecular Interventions, 5 (4), .
(doi:10.1124/mi.5.4.6).
Abstract
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors that control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. These findings together with the observation that several of these genes have human leukocyte antigen (HLA) class I ligands, have led to a flurry of investigation into how KIR participate in viral infections, autoimmune diseases and malignancies. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration.
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Published date: 2005
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Review Article
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Local EPrints ID: 27486
URI: http://eprints.soton.ac.uk/id/eprint/27486
ISSN: 1534-0384
PURE UUID: 29ae01bd-e7dc-4726-b955-5751044d3b3e
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Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 03:25
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Author:
Anthony P. Williams
Author:
Andrew R. Bateman
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