A randomised, double-blind trial of topical ketorolac vs artificial tears for the treatment of episcleritis


Williams, C.P.R., Browning, A.C., Sleep, T.J., Webber, S.K. and McGill, J.I. (2005) A randomised, double-blind trial of topical ketorolac vs artificial tears for the treatment of episcleritis Eye, 19, (7), pp. 739-742. (doi:10.1038/sj.eye.6701632).

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Description/Abstract

Purpose: To determine whether topical ketorolac (Acular) is more effective than artificial tears in treating the signs and symptoms of idiopathic episcleritis.
Methods: In this prospective, randomised, double-blind study, 38 eyes of 37 patients presenting with idiopathic episcleritis were allocated to receive either topical ketorolac (0.5%) or artificial tears three times a day for 3 weeks. The severity of patients' signs (episcleral injection and the number of clock hours affected) were recorded at weekly intervals. Patients' symptoms (perceived redness and pain scores) were recorded using a daily diary.
Results: There was no significant difference in the ophthalmic signs between the two groups at each assessment, including intensity of episcleral injection and the number of clock hours affected. No significant difference was found in the time to halve the baseline redness intensity scores (4.4 vs 6.1 days, P=0.2) or pain scores (3.6 vs 4.3 days, P=0.55). Significantly more patients on ketorolac reported stinging at the first follow-up visit (P<0.001).
Conclusion: Topical ketorolac is not significantly better than artificial tears in treating the signs or symptoms of idiopathic episcleritis.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/sj.eye.6701632
Additional Information: Clinical Study
ISSNs: 0950-222X (print)
Related URLs:
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ePrint ID: 27487
Date :
Date Event
2005Published
Date Deposited: 25 Apr 2006
Last Modified: 16 Apr 2017 22:30
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/27487

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