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A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment

Record type: Article

We investigated the safety, tolerability and efficacy of nefazodone and paroxetine in the continuation phase of treatment of depression. The study comprised a double-blind, parallel-group comparison over 4 months, of patients who had previously improved following random allocation to nefazodone or paroxetine during an 8-week acute treatment study. Assessments included Clinical Global Impression Scales, Hamilton Rating Scales for Depression and Anxiety, Montgomery-Asberg Depression Rating Scale and the Patient Global Assessment Scale, in addition to a review of reported adverse events, vital sign measurements, electrocardiograms and clinical laboratory tests. One hundred and eight patients participated in the continuation study (53 received paroxetine, 55 nefazodone) and 73 completed treatment. No clinically relevant differences in antidepressant efficacy were seen. Headache and somnolence were the most common reported adverse events in both treatment groups. Both nefazodone and paroxetine maintain their efficacy in continuation treatment, and both are generally well tolerated.

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Citation

Baldwin, David S., Hawley, Christopher J. and Mellors, Karen (2001) A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment Journal of Psychopharmacology, 15, (3), pp. 161-165.

More information

Published date: 2001
Keywords: continuation treatment, major depression, nefazodone, paroxetine

Identifiers

Local EPrints ID: 27517
URI: http://eprints.soton.ac.uk/id/eprint/27517
ISSN: 0269-8811
PURE UUID: e817ad42-5311-4d6b-a17c-10a32e35bb71

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: Christopher J. Hawley
Author: Karen Mellors

University divisions


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