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Sexual dysfunction associated with antidepressant drugs

Sexual dysfunction associated with antidepressant drugs
Sexual dysfunction associated with antidepressant drugs
The term ‘sexual dysfunction’ describes a disturbance in sexual desire and the psychophysiological changes that characterise the normal sexual response cycle, and cause marked personal distress and interpersonal difficulty. Epidemiological studies indicate that sexual dysfunction is common in the general population, but more common in depressed individuals in community settings and clinical samples. Most antidepressant drugs have adverse effects on sexual function, but accurate identification of the incidence of treatment-emergent dysfunction has proved troublesome. Furthermore, investigations of sexual dysfunction associated with antidepressants have one or more methodological flaws. There may be some advantages for bupropion, moclobemide, nefazodone and reboxetine over other antidepressants. Many approaches have been adopted for management of patients with sexual dysfunction associated with antidepressant treatment, including waiting for the problem to resolve, behavioural strategies to modify sexual technique, individual and couple psychotherapy, delaying the intake of antidepressants until after sexual activity, reduction in daily dosage, ‘drug holidays’, use of adjuvant treatments, and switching to a different antidepressant.
antidepressants, bupropion, mirtazapine, moclobemide, monoamine oxidase inhibitors (MAOIs), nefazodone, reboxetine, selective serotonin re-uptake inhibitors (SSRIs), sexual dysfunction, tricyclic antidepressants (TCAs)
1474-0338
457-470
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e

Baldwin, David S. (2004) Sexual dysfunction associated with antidepressant drugs. Expert Opinion on Drug Safety, 3 (5), 457-470. (doi:10.1517/14740338.3.5.457).

Record type: Article

Abstract

The term ‘sexual dysfunction’ describes a disturbance in sexual desire and the psychophysiological changes that characterise the normal sexual response cycle, and cause marked personal distress and interpersonal difficulty. Epidemiological studies indicate that sexual dysfunction is common in the general population, but more common in depressed individuals in community settings and clinical samples. Most antidepressant drugs have adverse effects on sexual function, but accurate identification of the incidence of treatment-emergent dysfunction has proved troublesome. Furthermore, investigations of sexual dysfunction associated with antidepressants have one or more methodological flaws. There may be some advantages for bupropion, moclobemide, nefazodone and reboxetine over other antidepressants. Many approaches have been adopted for management of patients with sexual dysfunction associated with antidepressant treatment, including waiting for the problem to resolve, behavioural strategies to modify sexual technique, individual and couple psychotherapy, delaying the intake of antidepressants until after sexual activity, reduction in daily dosage, ‘drug holidays’, use of adjuvant treatments, and switching to a different antidepressant.

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More information

Published date: 2004
Keywords: antidepressants, bupropion, mirtazapine, moclobemide, monoamine oxidase inhibitors (MAOIs), nefazodone, reboxetine, selective serotonin re-uptake inhibitors (SSRIs), sexual dysfunction, tricyclic antidepressants (TCAs)

Identifiers

Local EPrints ID: 27523
URI: http://eprints.soton.ac.uk/id/eprint/27523
ISSN: 1474-0338
PURE UUID: 85fdb0bc-677b-4718-921f-9727eb2399b0
ORCID for David S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

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Date deposited: 26 Apr 2006
Last modified: 22 Jun 2021 01:34

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