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A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies

A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies
A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies
Background: Depression is a common and distressing problem in the context of dementia, and is significantly more common in Dementia with Lewy bodies (DLB) than in Alzheimer’s disease. The neurochemical basis for depression in DLB has not been investigated.
Aim: To investigate the association between depression and 5HT transporter re-uptake binding in DLB patients. Method: A representative cohort of dementia patients received annual assessments, which included a standardised evaluation of depression until death. At post-mortem, (3H) cyanoimipramine autoradiography was used to quantify 5HT transporter re-uptake sites in the hippocampus and adjacent temporal cortex (Brodmann Area-BA 36, and 20); and parietal neocortex (BA 7a).
Results: Twenty-one cases were evaluated neurochemically, of whom seven had experienced a major depressive disorder. Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t=3.3, P=0.004; BA 7a area 3 t=3.8, P=0.001).
Conclusion: This preliminary report is important in challenging some of the assumptions about cortical monoamine functioning in depressed dementia.
depression, dementia, lewy bodies, alzheimer's disease, 5ht transporter
219-223
Ballard, Clive
e244c4e5-5dd4-4c66-9efb-6bf2006bdb7e
Johnson, Mary
680ac823-d2ee-437a-8bdd-94788927a608
Piggot, Margaret
b9b27092-0063-4508-83fc-e6c388a0f132
Perry, Robert
34194792-4c05-4b3b-a8f5-29892295608f
O'Brien, John
0906821d-4431-47e6-8155-27de5d7f9612
Rowan, Elise
1ac60f1d-e00c-4382-afae-4ce0c1813d04
Perry, Elaine
f24dce10-0464-41c2-9a7e-6c9ff3687923
Lantos, Peter
b11df872-5b67-4df1-bc1e-3e204eaca995
Cairns, Nigel
257323c8-3438-471d-b1d9-9b82c2be516e
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Ballard, Clive
e244c4e5-5dd4-4c66-9efb-6bf2006bdb7e
Johnson, Mary
680ac823-d2ee-437a-8bdd-94788927a608
Piggot, Margaret
b9b27092-0063-4508-83fc-e6c388a0f132
Perry, Robert
34194792-4c05-4b3b-a8f5-29892295608f
O'Brien, John
0906821d-4431-47e6-8155-27de5d7f9612
Rowan, Elise
1ac60f1d-e00c-4382-afae-4ce0c1813d04
Perry, Elaine
f24dce10-0464-41c2-9a7e-6c9ff3687923
Lantos, Peter
b11df872-5b67-4df1-bc1e-3e204eaca995
Cairns, Nigel
257323c8-3438-471d-b1d9-9b82c2be516e
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96

Ballard, Clive, Johnson, Mary, Piggot, Margaret, Perry, Robert, O'Brien, John, Rowan, Elise, Perry, Elaine, Lantos, Peter, Cairns, Nigel and Holmes, Clive (2006) A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. Journal of Affective Disorders, 69 (1-3), 219-223. (doi:10.1016/S0165-0327(00)00375-X).

Record type: Article

Abstract

Background: Depression is a common and distressing problem in the context of dementia, and is significantly more common in Dementia with Lewy bodies (DLB) than in Alzheimer’s disease. The neurochemical basis for depression in DLB has not been investigated.
Aim: To investigate the association between depression and 5HT transporter re-uptake binding in DLB patients. Method: A representative cohort of dementia patients received annual assessments, which included a standardised evaluation of depression until death. At post-mortem, (3H) cyanoimipramine autoradiography was used to quantify 5HT transporter re-uptake sites in the hippocampus and adjacent temporal cortex (Brodmann Area-BA 36, and 20); and parietal neocortex (BA 7a).
Results: Twenty-one cases were evaluated neurochemically, of whom seven had experienced a major depressive disorder. Major depression was associated with a significant preservation of 5HT transporter re-uptake sites in the parietal neocortex compared with non-affected cases (BA 7a area 1 t=3.3, P=0.004; BA 7a area 3 t=3.8, P=0.001).
Conclusion: This preliminary report is important in challenging some of the assumptions about cortical monoamine functioning in depressed dementia.

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More information

Published date: 2006
Keywords: depression, dementia, lewy bodies, alzheimer's disease, 5ht transporter

Identifiers

Local EPrints ID: 27531
URI: http://eprints.soton.ac.uk/id/eprint/27531
PURE UUID: d64d5caf-6ad6-4377-8674-c5fb65e52fce
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

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Date deposited: 25 Apr 2006
Last modified: 10 Dec 2019 01:50

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Contributors

Author: Clive Ballard
Author: Mary Johnson
Author: Margaret Piggot
Author: Robert Perry
Author: John O'Brien
Author: Elise Rowan
Author: Elaine Perry
Author: Peter Lantos
Author: Nigel Cairns
Author: Clive Holmes ORCID iD

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