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Immunotherapy for Alzheimer's disease and other dementias

Immunotherapy for Alzheimer's disease and other dementias
Immunotherapy for Alzheimer's disease and other dementias
Purpose of review: The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-[beta] accumulation in Alzheimer's disease.
Recent findings: In both transgenic mouse models and in two trials of amyloid-[beta] immunotherapy for human Alzheimer's disease, active immunization with amyloid-[beta] 1-42 results in the removal of amyloid-[beta] plaques from the cerebral cortex associated with, in the mouse models, improvement in cognitive function. Cerebral amyloid angiopathy and neurofibrillary tangles persist, however, and there is also concern about T lymphocyte immune reactions in the meninges in the human cases. Active immunization schedules are being developed to minimize T lymphocyte reactions and to maximize antibody production and passive immunization protocols are being devised. Immunotherapy for removal of the proteins which accumulate in other neurodegenerative disorders associated with dementia such as prion proteins and [alpha]-synuclein are in the early stages of development.
Summary: Dementias in the elderly are an increasing medical, social and economic problem and current treatments are only effective. In the majority of dementias, proteins accumulate within cells and in the extracellular compartments of the brain. In the most common dementia, Alzheimer's disease, amyloid-[beta] accumulates as plaques in the extracellular space of the grey matter and in artery walls as cerebral amyloid angiopathy and tau protein accumulates as neurofibrillary tangles within neurons.
1350-7540
720-725
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Nicoll, JAR.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Weller, RO.
4a501831-e38a-4d39-a125-d7141d6c667b
Boche, D.
bdcca10e-6302-4dd0-919f-67218f7e0d61
Nicoll, JAR.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Weller, RO.
4a501831-e38a-4d39-a125-d7141d6c667b

Boche, D., Nicoll, JAR. and Weller, RO. (2005) Immunotherapy for Alzheimer's disease and other dementias. Current Opinion in Neurology, 18 (6), 720-725.

Record type: Article

Abstract

Purpose of review: The aim of this article is to review the role of immunotherapy in the removal of proteins which accumulate abnormally in neurodegenerative disorders associated with dementia, in particular amyloid-[beta] accumulation in Alzheimer's disease.
Recent findings: In both transgenic mouse models and in two trials of amyloid-[beta] immunotherapy for human Alzheimer's disease, active immunization with amyloid-[beta] 1-42 results in the removal of amyloid-[beta] plaques from the cerebral cortex associated with, in the mouse models, improvement in cognitive function. Cerebral amyloid angiopathy and neurofibrillary tangles persist, however, and there is also concern about T lymphocyte immune reactions in the meninges in the human cases. Active immunization schedules are being developed to minimize T lymphocyte reactions and to maximize antibody production and passive immunization protocols are being devised. Immunotherapy for removal of the proteins which accumulate in other neurodegenerative disorders associated with dementia such as prion proteins and [alpha]-synuclein are in the early stages of development.
Summary: Dementias in the elderly are an increasing medical, social and economic problem and current treatments are only effective. In the majority of dementias, proteins accumulate within cells and in the extracellular compartments of the brain. In the most common dementia, Alzheimer's disease, amyloid-[beta] accumulates as plaques in the extracellular space of the grey matter and in artery walls as cerebral amyloid angiopathy and tau protein accumulates as neurofibrillary tangles within neurons.

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More information

Published date: December 2005

Identifiers

Local EPrints ID: 27536
URI: https://eprints.soton.ac.uk/id/eprint/27536
ISSN: 1350-7540
PURE UUID: 71b54453-a693-4385-836f-96eabd2a5b76
ORCID for D. Boche: ORCID iD orcid.org/0000-0002-5884-130X
ORCID for JAR. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 06 Jun 2018 12:52

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