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Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies

Court, J., Ballard, C., Piggot, M., Johnson, M., O'Brien, J.T, Holmes, C., Cairns, N., Lantos, P., Perry, R., Jaros, E. and Perry, E. (2001) Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies Pharmacology Biochemistry & Behaviour. Sex and Drugs, 70, (4), pp. 571-579. (doi:10.1016/S0091-3057(01)00644-X).

Record type: Article

Abstract

Patients with dementia with Lewy bodies (DLB) commonly experience psychotic symptoms, most notably visual hallucinations. Previously, it has been shown that visual hallucinations in DLB are associated with reduced cortical choline acetyltransferase activity, a marker of cholinergic innervation, but not with predominantly postsynaptic muscarinic M1 receptor binding. In the present investigation, nicotinic acetylcholine receptor (nAChR) levels in the temporal cortex (Brodmann's areas [BA] 20 and 36) were measured in a group of 24 prospectively assessed DLB patients; comparisons were made between groups with or without visual and auditory hallucinations and delusional misidentification. Visual hallucinations and delusional misidentification were associated with lower [125I]?bungarotoxin binding in areas 36 and 20 (P<.05), but not with changes in [3H]epibatidine binding. There were no significant associations with auditory hallucinations. [3H]epibatidine, but not [125I]?bungarotoxin, binding for all DLB cases was reduced compared to controls (P<.001). Loss of cortical ?7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia.

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Published date: 2001
Keywords: nicotinic acetylcholine receptors, ?7 subunits, dementia with lewy bodies, visual hallucinations, delusional misidentification, temporal cortex

Identifiers

Local EPrints ID: 27553
URI: http://eprints.soton.ac.uk/id/eprint/27553
ISSN: 0091-3057
PURE UUID: 03113408-4130-4c73-a0d1-40d702d12d6d

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Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: J. Court
Author: C. Ballard
Author: M. Piggot
Author: M. Johnson
Author: J.T O'Brien
Author: C. Holmes
Author: N. Cairns
Author: P. Lantos
Author: R. Perry
Author: E. Jaros
Author: E. Perry

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