The University of Southampton
University of Southampton Institutional Repository

Tumour necrosis factor-?gene polymorphisms and Alzheimer's disease

Tumour necrosis factor-?gene polymorphisms and Alzheimer's disease
Tumour necrosis factor-?gene polymorphisms and Alzheimer's disease
Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-?), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-? gene to respectively examine TNF-? polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-? point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when ?308/A, ?238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P=0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.
alzheimer's disease, tumour necrosis factor-alpha, polymorphisms, hla-drb1*03
0304-3940
61-65
Culpan, Doris
29a1fbcf-11f5-48fe-bc94-bdaf5e91ff8d
MacGowan, Sian H.
ec0db9d1-29d1-43db-8ac7-10593010a8c7
Ford, Julia M.
b6ddc35f-a38b-43e8-a6cc-adbbf23d966b
Nicoll, James A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Griffin, W. Sue
c953f73b-bf8a-4738-8f2e-97e633194281
Dewar, Deborah
eda0cc13-11d5-48f4-9c58-5f3aa1d12aa5
Cairns, Nigel J.
7e1ba6bc-e161-47e5-9ed0-b06190986dd4
Hughes, Anthony
395ae4ef-2bc5-413d-842b-17f5d28cd2c9
Kehoe, Patrick G.
c3d54052-f508-4091-86ce-ec4727ef3c9a
Wilcock, Gordon K.
caae0bad-4a40-4ef5-9c19-ea4cb741a0e0
Culpan, Doris
29a1fbcf-11f5-48fe-bc94-bdaf5e91ff8d
MacGowan, Sian H.
ec0db9d1-29d1-43db-8ac7-10593010a8c7
Ford, Julia M.
b6ddc35f-a38b-43e8-a6cc-adbbf23d966b
Nicoll, James A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Griffin, W. Sue
c953f73b-bf8a-4738-8f2e-97e633194281
Dewar, Deborah
eda0cc13-11d5-48f4-9c58-5f3aa1d12aa5
Cairns, Nigel J.
7e1ba6bc-e161-47e5-9ed0-b06190986dd4
Hughes, Anthony
395ae4ef-2bc5-413d-842b-17f5d28cd2c9
Kehoe, Patrick G.
c3d54052-f508-4091-86ce-ec4727ef3c9a
Wilcock, Gordon K.
caae0bad-4a40-4ef5-9c19-ea4cb741a0e0

Culpan, Doris, MacGowan, Sian H., Ford, Julia M., Nicoll, James A., Griffin, W. Sue, Dewar, Deborah, Cairns, Nigel J., Hughes, Anthony, Kehoe, Patrick G. and Wilcock, Gordon K. (2003) Tumour necrosis factor-?gene polymorphisms and Alzheimer's disease. Neuroscience Letters, 350 (1), 61-65. (doi:10.1016/S0304-3940(03)00854-1).

Record type: Article

Abstract

Recent findings suggest that production of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-?), is increased in the brains of people with Alzheimer's disease (AD). We used direct sequencing methods on a section of the enhancer/promoter region and on a smaller fragment located 10.5 kb upstream of the TNF-? gene to respectively examine TNF-? polymorphisms and TNF-a and -b microsatellite alleles in a cohort of 235 post-mortem confirmed AD and 130 control cases. None of the TNF-? point mutations or microsatellite alleles investigated proved to be independent risk factors for AD. However, when ?308/A, ?238/G and TNF-a2 were examined as a 2-1-2 haplotype, we observed that the absence of that haplotype was significantly associated with AD (P=0.014, Fisher's exact test) suggesting that the 2-1-2 haplotype may be protective against AD.

This record has no associated files available for download.

More information

Published date: 2003
Keywords: alzheimer's disease, tumour necrosis factor-alpha, polymorphisms, hla-drb1*03

Identifiers

Local EPrints ID: 27554
URI: http://eprints.soton.ac.uk/id/eprint/27554
ISSN: 0304-3940
PURE UUID: 97ff7876-3cd9-4482-a991-5ad007c8dac1
ORCID for James A. Nicoll: ORCID iD orcid.org/0000-0002-9444-7246

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 09 Jan 2022 03:09

Export record

Altmetrics

Contributors

Author: Doris Culpan
Author: Sian H. MacGowan
Author: Julia M. Ford
Author: James A. Nicoll ORCID iD
Author: W. Sue Griffin
Author: Deborah Dewar
Author: Nigel J. Cairns
Author: Anthony Hughes
Author: Patrick G. Kehoe
Author: Gordon K. Wilcock

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×