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Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion

Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion
Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion
Several lines of evidence suggest that the auditory evoked potential (AEP) augmenting/reducing slope may serve as a biological marker of central serotonergic activity. According to Hegerl and Juckel (Biol. Psychiatry, 33, 1993, 173), reduced serotonergic activity is hypothesized to increase the slope of the AEP amplitude stimulus intensity function (ASF-slope). Hints for this hypothesis were investigated by employing the acute tryptophan depletion paradigm in 18 healthy females. A within-subject, placebo controlled double-blind cross over design was used for that purpose. Subjects ingested both a 50 g amino-acid drink with (placebo condition) and without tryptophan (depletion condition). With respect to the N1/P2-slope, test–retest reliability of a 1 week interval ranged between r=0.56 and 0.58 for the pre-ingestion baseline recording sessions. Affect was not altered by tryptophan depletion and not related to the ASF-slope. The comparison between placebo and depletion conditions did not reveal significant alterations of the ASF-slope, neither after 5 nor 6 h post-ingestion. Thus, the results do not support the assumption of the ASF-slope reflecting central serotonergic function.
augmenting/reducing, auditory evoked potentials, N1/P2, tryptophan depletion
0301-0511
121-133
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Kürschner, Katharina
55c3923c-39e6-4b97-b7b2-daa4182636b2
Kranczioch, Cornelia
c5d9d3fb-2b54-4ae0-85dd-fb1ae11aea4f
Hebenstreit, Jörg
1807c39f-5b96-4880-8648-20444c1a5b00
Maercker, Andreas
c8c1b9a1-07e0-4086-8c97-a3c259f33aa6
Beauducel, André
3313dcba-b8a2-4a64-94c1-14abaecbc90e
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c
Debener, Stefan
e6bf9143-09a8-45c0-8536-3564885375d4
Strobel, Alexander
272b7bac-eae5-4649-9a2d-51416f75275a
Kürschner, Katharina
55c3923c-39e6-4b97-b7b2-daa4182636b2
Kranczioch, Cornelia
c5d9d3fb-2b54-4ae0-85dd-fb1ae11aea4f
Hebenstreit, Jörg
1807c39f-5b96-4880-8648-20444c1a5b00
Maercker, Andreas
c8c1b9a1-07e0-4086-8c97-a3c259f33aa6
Beauducel, André
3313dcba-b8a2-4a64-94c1-14abaecbc90e
Brocke, Burkhard
60fbd65b-62d6-4eb0-ba6f-dd2b7148ef9c

Debener, Stefan, Strobel, Alexander, Kürschner, Katharina, Kranczioch, Cornelia, Hebenstreit, Jörg, Maercker, Andreas, Beauducel, André and Brocke, Burkhard (2002) Is auditory evoked potential augmenting/reducing affected by acute tryptophan depletion. Biological Psychology, 59 (2), 121-133. (doi:10.1016/S0301-0511(01)00132-6).

Record type: Article

Abstract

Several lines of evidence suggest that the auditory evoked potential (AEP) augmenting/reducing slope may serve as a biological marker of central serotonergic activity. According to Hegerl and Juckel (Biol. Psychiatry, 33, 1993, 173), reduced serotonergic activity is hypothesized to increase the slope of the AEP amplitude stimulus intensity function (ASF-slope). Hints for this hypothesis were investigated by employing the acute tryptophan depletion paradigm in 18 healthy females. A within-subject, placebo controlled double-blind cross over design was used for that purpose. Subjects ingested both a 50 g amino-acid drink with (placebo condition) and without tryptophan (depletion condition). With respect to the N1/P2-slope, test–retest reliability of a 1 week interval ranged between r=0.56 and 0.58 for the pre-ingestion baseline recording sessions. Affect was not altered by tryptophan depletion and not related to the ASF-slope. The comparison between placebo and depletion conditions did not reveal significant alterations of the ASF-slope, neither after 5 nor 6 h post-ingestion. Thus, the results do not support the assumption of the ASF-slope reflecting central serotonergic function.

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More information

Published date: 2002
Keywords: augmenting/reducing, auditory evoked potentials, N1/P2, tryptophan depletion

Identifiers

Local EPrints ID: 27561
URI: http://eprints.soton.ac.uk/id/eprint/27561
ISSN: 0301-0511
PURE UUID: bade1969-6073-4356-a9b9-225953e3a138

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Date deposited: 25 Apr 2006
Last modified: 15 Jul 2019 19:11

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Contributors

Author: Stefan Debener
Author: Alexander Strobel
Author: Katharina Kürschner
Author: Cornelia Kranczioch
Author: Jörg Hebenstreit
Author: Andreas Maercker
Author: André Beauducel
Author: Burkhard Brocke

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