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Does lithium therapy protect against the onset of dementia

Does lithium therapy protect against the onset of dementia
Does lithium therapy protect against the onset of dementia
Lithium compounds might theoretically play a role in preventing dementia by inhibiting formation both of beta amyloid and hyper phosphorylated tau protein. We carried out a case-control study to assess any possible clinical effects of lithium therapy on the diagnosis of dementia, using data from the General Practice Research Database, which collects routine data from primary care patients in the UK. Patients who received lithium had a higher risk of a diagnosis of dementia compared with those who did not (adjusted odds ratio 1.8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia.
0893-0341
20-22
Dunn, Nick
181a3a1f-5ff7-4150-ad87-457fffb758ed
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Mullee, Mark
fd3f91c3-5e95-4f56-8d73-260824eeb362
Dunn, Nick
181a3a1f-5ff7-4150-ad87-457fffb758ed
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Mullee, Mark
fd3f91c3-5e95-4f56-8d73-260824eeb362

Dunn, Nick, Holmes, Clive and Mullee, Mark (2005) Does lithium therapy protect against the onset of dementia. Alzheimer Disease and Associated Disorders, 19 (1), 20-22.

Record type: Article

Abstract

Lithium compounds might theoretically play a role in preventing dementia by inhibiting formation both of beta amyloid and hyper phosphorylated tau protein. We carried out a case-control study to assess any possible clinical effects of lithium therapy on the diagnosis of dementia, using data from the General Practice Research Database, which collects routine data from primary care patients in the UK. Patients who received lithium had a higher risk of a diagnosis of dementia compared with those who did not (adjusted odds ratio 1.8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia.

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More information

Published date: 2005

Identifiers

Local EPrints ID: 27568
URI: http://eprints.soton.ac.uk/id/eprint/27568
ISSN: 0893-0341
PURE UUID: dfb91d71-5c4f-441b-965e-aa8597870be0
ORCID for Clive Holmes: ORCID iD orcid.org/0000-0003-1999-6912

Catalogue record

Date deposited: 25 Apr 2006
Last modified: 10 Jan 2022 02:42

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Contributors

Author: Nick Dunn
Author: Clive Holmes ORCID iD
Author: Mark Mullee

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