Does lithium therapy protect against the onset of dementia
Does lithium therapy protect against the onset of dementia
Lithium compounds might theoretically play a role in preventing dementia by inhibiting formation both of beta amyloid and hyper phosphorylated tau protein. We carried out a case-control study to assess any possible clinical effects of lithium therapy on the diagnosis of dementia, using data from the General Practice Research Database, which collects routine data from primary care patients in the UK. Patients who received lithium had a higher risk of a diagnosis of dementia compared with those who did not (adjusted odds ratio 1.8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia.
20-22
Dunn, Nick
181a3a1f-5ff7-4150-ad87-457fffb758ed
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Mullee, Mark
fd3f91c3-5e95-4f56-8d73-260824eeb362
2005
Dunn, Nick
181a3a1f-5ff7-4150-ad87-457fffb758ed
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Mullee, Mark
fd3f91c3-5e95-4f56-8d73-260824eeb362
Dunn, Nick, Holmes, Clive and Mullee, Mark
(2005)
Does lithium therapy protect against the onset of dementia.
Alzheimer Disease and Associated Disorders, 19 (1), .
Abstract
Lithium compounds might theoretically play a role in preventing dementia by inhibiting formation both of beta amyloid and hyper phosphorylated tau protein. We carried out a case-control study to assess any possible clinical effects of lithium therapy on the diagnosis of dementia, using data from the General Practice Research Database, which collects routine data from primary care patients in the UK. Patients who received lithium had a higher risk of a diagnosis of dementia compared with those who did not (adjusted odds ratio 1.8, 95% CI 1.1-2.8). There was a trend toward increasing risk with increasing numbers of lithium prescriptions. This evidence does not support the use of lithium for preventing dementia.
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Published date: 2005
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Local EPrints ID: 27568
URI: http://eprints.soton.ac.uk/id/eprint/27568
ISSN: 0893-0341
PURE UUID: dfb91d71-5c4f-441b-965e-aa8597870be0
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Date deposited: 25 Apr 2006
Last modified: 28 Apr 2022 01:45
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Author:
Nick Dunn
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