Long-term intracerebral inflammatory response after traumatic brain injury
Long-term intracerebral inflammatory response after traumatic brain injury
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
traumatic brain injury, inflammation, neurodegeneration, cytokine cycle
97-104
Gentleman, S.M.
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Leclercq, P.D.
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Moyes, L.
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Graham, D.I.
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Smith, C.
2019b8d8-ee85-40ff-9bb1-76916a21de6b
Griffin, W.S.
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Nicoll, J.A.
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16 December 2004
Gentleman, S.M.
5b93cc56-1fa8-4406-af6f-4177199da72a
Leclercq, P.D.
cbd9f8a0-8dfe-4714-9092-ab720a6fc141
Moyes, L.
e4c11831-4f08-400b-81c3-a8325335a4a3
Graham, D.I.
0b1c9c9e-94b2-44fa-b189-8e04501b3a67
Smith, C.
2019b8d8-ee85-40ff-9bb1-76916a21de6b
Griffin, W.S.
c1c33c3d-15aa-453c-b3d7-cf9b2256db3e
Nicoll, J.A.
88c0685f-000e-4eb7-8f72-f36b4985e8ed
Gentleman, S.M., Leclercq, P.D., Moyes, L., Graham, D.I., Smith, C., Griffin, W.S. and Nicoll, J.A.
(2004)
Long-term intracerebral inflammatory response after traumatic brain injury.
Forensic Science International, 146 (2-3), .
(doi:10.1016/j.forsciint.2004.06.027).
Abstract
Epidemiological and pathological studies suggest that head injury is a significant risk factor for subsequent neurodegeneration and cognitive decline in later life. The precise mechanisms for the development of post-traumatic neurodegenerative change are unclear but we hypothesize that persistence of inflammatory processes in the brain may play a key role and that some individuals are more susceptible to such changes based on their genetic make-up. In support of this hypothesis we present evidence of persistent elevated microglial activity in long-term survivors of head injury and the suggestion of an association between the extent of this activity and interleukin-1 genotype.
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Published date: 16 December 2004
Keywords:
traumatic brain injury, inflammation, neurodegeneration, cytokine cycle
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Local EPrints ID: 27576
URI: http://eprints.soton.ac.uk/id/eprint/27576
ISSN: 0379-0738
PURE UUID: 276bfd8f-42cf-4279-a936-fa53e409c252
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Date deposited: 26 Apr 2006
Last modified: 16 Mar 2024 03:26
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Author:
S.M. Gentleman
Author:
P.D. Leclercq
Author:
L. Moyes
Author:
D.I. Graham
Author:
C. Smith
Author:
W.S. Griffin
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