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Long-term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial

Grace, Janet, Daniel, Sarah, Stevens, Timothy, Shankar, K. Shankar, Walker, Zuzanna, Byrne, E. Jane, Butler, Susan, Wilkinson, David, Woolford, Jan, Waite, Jonathon and McKeith, Ian G. (2001) Long-term use of rivastigmine in patients with dementia with Lewy bodies: an open-label trial International Psychogeriatrics, 13, (2), pp. 199-205. (doi:10.1017/S104161020100758X).

Record type: Article


Patients with dementia with lewy bodies (DLB) have progressive deficits in cognition, parkinsonism, and neuropsychiatric symptoms. Cholinesterase inhibitors have been used to ameliorate cognitive decline and neuropsychiatric symptoms in short-term trials. In this study, patients with DLB were treated with rivastigmine up to 96 weeks. Improvement from baseline was seen in cognitive function as measured by the Mini-Mental State Examination (MMSE), and neuropsychiatric symptoms as measured by the Neuropsychiatric Inventory (NPI) over the first 24 weeks of treatment. By 96 weeks, neither the MMSE scores nor the NPI scores were significantly worse than at baseline.

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Published date: 2001


Local EPrints ID: 27578
ISSN: 1041-6102
PURE UUID: 9efd93f5-c4f6-4c7c-b466-e8c832e615f1

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Date deposited: 28 Apr 2006
Last modified: 17 Jul 2017 16:04

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Author: Janet Grace
Author: Sarah Daniel
Author: Timothy Stevens
Author: K. Shankar Shankar
Author: Zuzanna Walker
Author: E. Jane Byrne
Author: Susan Butler
Author: David Wilkinson
Author: Jan Woolford
Author: Jonathon Waite
Author: Ian G. McKeith

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