Seizure induced dentate neurogenesis does not diminish with age in rats
Seizure induced dentate neurogenesis does not diminish with age in rats
Neurogenesis in the mammalian dentate gyrus occurs throughout life, is believed to be important for the laying down of episodic memory and diminishes significantly with increasing age. Pathological insults such as seizures, hypoxia and traumatic brain injury increase dentate neurogenesis compared to age matched controls. Using unilateral intracerebroventricular kainate we show that although baseline neurogenesis is significantly lower in 3 month old rats compared to 1 month old rats, kainate increases neurogenesis to reach similar levels in both age groups. Additionally, this effect is bilateral after a unilateral intracerebroventricular kainate injection. We conclude that the potential for dentate neurogenesis is maintained despite diminishing baseline levels with increasing age and that injury signals override the age related suppression of neurogenesis.
seizures, neurogenesis, age, dentate gyrus
235-238
Gray, W.P.
e0ba5a65-bd74-4a4f-b640-5abf64fbb377
May, K.
431d753d-559a-4c57-8459-643ae1824981
Sundström, L.E.
e5f76f38-e8a1-43d6-9901-8075cf233975
2002
Gray, W.P.
e0ba5a65-bd74-4a4f-b640-5abf64fbb377
May, K.
431d753d-559a-4c57-8459-643ae1824981
Sundström, L.E.
e5f76f38-e8a1-43d6-9901-8075cf233975
Gray, W.P., May, K. and Sundström, L.E.
(2002)
Seizure induced dentate neurogenesis does not diminish with age in rats.
Neuroscience Letters, 330 (3), .
(doi:10.1016/S0304-3940(02)00810-8).
Abstract
Neurogenesis in the mammalian dentate gyrus occurs throughout life, is believed to be important for the laying down of episodic memory and diminishes significantly with increasing age. Pathological insults such as seizures, hypoxia and traumatic brain injury increase dentate neurogenesis compared to age matched controls. Using unilateral intracerebroventricular kainate we show that although baseline neurogenesis is significantly lower in 3 month old rats compared to 1 month old rats, kainate increases neurogenesis to reach similar levels in both age groups. Additionally, this effect is bilateral after a unilateral intracerebroventricular kainate injection. We conclude that the potential for dentate neurogenesis is maintained despite diminishing baseline levels with increasing age and that injury signals override the age related suppression of neurogenesis.
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Published date: 2002
Keywords:
seizures, neurogenesis, age, dentate gyrus
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Local EPrints ID: 27580
URI: http://eprints.soton.ac.uk/id/eprint/27580
ISSN: 0304-3940
PURE UUID: 65bde382-994d-4488-9895-2458f43a9790
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Date deposited: 25 Apr 2006
Last modified: 15 Mar 2024 07:19
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Author:
W.P. Gray
Author:
K. May
Author:
L.E. Sundström
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