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Neuropathological assessment of artemether-treated severe malaria

Record type: Article

In animals, high doses of intramuscular artemether and artemotil have been shown to cause an unusual pattern of selective damage to certain brainstem nuclei, especially those implicated in hearing and balance. We aimed to investigate whether a similar pattern arises in human adults. We examined the brainstems of adults who died after treatment with high dose artemether or quinine for severe falciparum malaria for evidence of a pattern of selective neuronal damage. Neuropathological findings were similar in recipients of quinine (n=15) and artemether (n=6; total artemether doses received 4-44 mg/kg). No evidence was recorded for artemether-induced neurotoxic effects.

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Citation

Hien, T.T. T. G., Mai, N.T., Phu, N.H., Bethell, D., Blakemore, W.F., Cavanagh, J.B., Dayan, A., Medana, I., Weller, R.O., Day, N.P. and White, N.J. (2003) Neuropathological assessment of artemether-treated severe malaria The Lancet, 362, (9380), pp. 295-296. (doi:10.1016/S0140-6736(03)13974-8).

More information

Published date: 2003
Organisations: Clinical Neurosciences

Identifiers

Local EPrints ID: 27584
URI: http://eprints.soton.ac.uk/id/eprint/27584
ISSN: 0140-6736
PURE UUID: 3565f9e0-1735-4cda-a42f-a08adbab9577

Catalogue record

Date deposited: 27 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: T.T. T. G. Hien
Author: N.T. Mai
Author: N.H. Phu
Author: D. Bethell
Author: W.F. Blakemore
Author: J.B. Cavanagh
Author: A. Dayan
Author: I. Medana
Author: R.O. Weller
Author: N.P. Day
Author: N.J. White

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