Neuropathological assessment of artemether-treated severe malaria

Hien, T.T. T. G., Mai, N.T., Phu, N.H., Bethell, D., Blakemore, W.F., Cavanagh, J.B., Dayan, A., Medana, I., Weller, R.O., Day, N.P. and White, N.J. (2003) Neuropathological assessment of artemether-treated severe malaria Lancet, 362, (9380), pp. 295-296. (doi:10.1016/S0140-6736(03)13974-8).


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In animals, high doses of intramuscular artemether and artemotil have been shown to cause an unusual pattern of selective damage to certain brainstem nuclei, especially those implicated in hearing and balance. We aimed to investigate whether a similar pattern arises in human adults. We examined the brainstems of adults who died after treatment with high dose artemether or quinine for severe falciparum malaria for evidence of a pattern of selective neuronal damage. Neuropathological findings were similar in recipients of quinine (n=15) and artemether (n=6; total artemether doses received 4-44 mg/kg). No evidence was recorded for artemether-induced neurotoxic effects.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/S0140-6736(03)13974-8
ISSNs: 0140-6736 (print)
ePrint ID: 27584
Date :
Date Event
Date Deposited: 27 Apr 2006
Last Modified: 16 Apr 2017 22:29
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