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Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation

Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation
Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation
This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.
alzheimers disease, genetics, behaviour
0022-3050
777-779
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Smith, H.R.
6d937055-4bf8-498f-8ddc-4d7cb4f63428
Arranz, M.
6c4ffe96-7eb0-4e77-9c17-306887497187
Collier, D.
d91ab590-d1ea-45ff-b9e3-31828924569c
Powell, J.
1d6c27f4-dc09-4347-b580-df054b2f9cc9
Lovestone, S.
482e0c1a-10cf-45fb-8631-bf32ca331104
Holmes, C.
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Smith, H.R.
6d937055-4bf8-498f-8ddc-4d7cb4f63428
Arranz, M.
6c4ffe96-7eb0-4e77-9c17-306887497187
Collier, D.
d91ab590-d1ea-45ff-b9e3-31828924569c
Powell, J.
1d6c27f4-dc09-4347-b580-df054b2f9cc9
Lovestone, S.
482e0c1a-10cf-45fb-8631-bf32ca331104

Holmes, C., Smith, H.R., Arranz, M., Collier, D., Powell, J. and Lovestone, S. (2001) Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation. Journal of Neurology Neurosurgery and Psychiatry, 71 (6), 777-779.

Record type: Article

Abstract

This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.

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More information

Published date: 2001
Keywords: alzheimers disease, genetics, behaviour

Identifiers

Local EPrints ID: 27592
URI: http://eprints.soton.ac.uk/id/eprint/27592
ISSN: 0022-3050
PURE UUID: 6b5feda1-a7ff-45d1-8409-ca95a3bdb83f
ORCID for C. Holmes: ORCID iD orcid.org/0000-0003-1999-6912

Catalogue record

Date deposited: 26 Apr 2006
Last modified: 09 Jan 2022 03:00

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Contributors

Author: C. Holmes ORCID iD
Author: H.R. Smith
Author: M. Arranz
Author: D. Collier
Author: J. Powell
Author: S. Lovestone

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