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Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation

Holmes, C., Smith, H.R., Arranz, M., Collier, D., Powell, J. and Lovestone, S. (2001) Psychosis and aggression in Alzheimer's disease: the effect of dopamine receptor gene variation Journal of Neurology Neurosurgery and Psychiatry, 71, (6), pp. 777-779.

Record type: Article


This study investigated possible associations between selected polymorphisms in the dopamine receptor genes DRD1 and DRD3 with the presence of psychotic phenomena or aggressive behaviour in a community based cohort of 134 patients with late onset Alzheimer's disease. An association was found between the presence of psychotic symptoms and aggressive behaviour and the DRD1 polymorphism and between the presence of psychosis, but not aggression, and the DRD3 polymorphism. Specifically, carriers of the DRD1 B2 allele were more likely to be aggressive or experience hallucinations whereas homozygous carriers of the DRD3 1 allele were more likely to experience delusions.

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Published date: 2001
Keywords: alzheimers disease, genetics, behaviour


Local EPrints ID: 27592
ISSN: 0022-3050
PURE UUID: 6b5feda1-a7ff-45d1-8409-ca95a3bdb83f

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Date deposited: 26 Apr 2006
Last modified: 17 Jul 2017 16:04

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Author: C. Holmes
Author: H.R. Smith
Author: M. Arranz
Author: D. Collier
Author: J. Powell
Author: S. Lovestone

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