Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
Depression in Alzheimer's disease: the effect of serotonin receptor gene variation
This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.
genetics, behavior, 5-ht2a, 5ht2c
40-43
Holmes, Clive
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Arranz, Maria
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Collier, David
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Powell, John
0616c5bf-0ce6-48ef-9b89-45a72529beb1
Lovestone, Simon
8c74cdb9-c6cc-4f60-8ad4-beaf5b526040
2003
Holmes, Clive
ada5abf3-8459-4cf7-be40-3f4e9391cc96
Arranz, Maria
f5d01b87-cf99-4829-9f2d-d0d4a69c6113
Collier, David
4344cb08-3c84-43e7-b4de-badd6705395d
Powell, John
0616c5bf-0ce6-48ef-9b89-45a72529beb1
Lovestone, Simon
8c74cdb9-c6cc-4f60-8ad4-beaf5b526040
Holmes, Clive, Arranz, Maria, Collier, David, Powell, John and Lovestone, Simon
(2003)
Depression in Alzheimer's disease: the effect of serotonin receptor gene variation.
American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics, 119B (1), .
(doi:10.1002/ajmg.b.10068).
Abstract
This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.
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Published date: 2003
Keywords:
genetics, behavior, 5-ht2a, 5ht2c
Identifiers
Local EPrints ID: 27598
URI: http://eprints.soton.ac.uk/id/eprint/27598
ISSN: 1552-4841
PURE UUID: 913cc1d4-f6ea-42ea-a896-2039bf1663a6
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Date deposited: 25 Apr 2006
Last modified: 16 Mar 2024 03:06
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Contributors
Author:
Maria Arranz
Author:
David Collier
Author:
John Powell
Author:
Simon Lovestone
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