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Depression in Alzheimer's disease: the effect of serotonin receptor gene variation

Record type: Article

This study investigated possible associations between selected polymorphisms in the serotonin receptor genes, 5-HT2A and 5-HT2C, with the presence of co-morbid depressive illness at baseline in a community based cohort of 158 patients with late onset patients with Alzheimer's disease (AD). An association was found between the presence of major depressive illness at baseline and both the 5-HT2A and 5-HT2C polymorphisms. Specifically, homozygous carriers of the 5-HT2A C102 allele were five times more likely to have major depressive illness than heterozygotes. In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele.

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Citation

Holmes, Clive, Arranz, Maria, Collier, David, Powell, John and Lovestone, Simon (2003) Depression in Alzheimer's disease: the effect of serotonin receptor gene variation American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 119B, (1), pp. 40-43. (doi:10.1002/ajmg.b.10068).

More information

Published date: 2003
Keywords: genetics, behavior, 5-ht2a, 5ht2c

Identifiers

Local EPrints ID: 27598
URI: http://eprints.soton.ac.uk/id/eprint/27598
ISSN: 1552-4841
PURE UUID: 913cc1d4-f6ea-42ea-a896-2039bf1663a6

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Date deposited: 25 Apr 2006
Last modified: 17 Jul 2017 16:04

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Contributors

Author: Clive Holmes
Author: Maria Arranz
Author: David Collier
Author: John Powell
Author: Simon Lovestone

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